Drugs / BMS-955176
last change Oct 2018 re-read 2 minutes ago

BMS-955176

also known as GSK3532795

Other / unclassified

Developed for
HIV infectious disease
Investigated by
ViiV Healthcare · GlaxoSmithKline

Trials 10 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 17 trials
Phase 1 NCT02715479 Apr → May 2016 HIV infectious disease ViiV Healthcare Completed No outcome recorded
Phase 1 NCT02578277 Nov → Dec 2015 HIV infectious disease ViiV Healthcare Completed No outcome recorded
Phase 1 NCT02576119 Oct 2015 → Feb 2016 HIV infectious disease ViiV Healthcare Terminated No outcome recorded
Phase 1 NCT02273947 Oct 2014 → Aug 2016 HIV infectious disease ViiV Healthcare Completed No outcome recorded
Phase 1 NCT02206711 Aug → Sep 2014 HIV infectious disease ViiV Healthcare Completed No outcome recorded
Phase 1 NCT02157467 Jun → Aug 2014 HIV infectious disease ViiV Healthcare Completed No outcome recorded
Phase 1 NCT02095886 Mar → Jul 2014 HIV infectious disease ViiV Healthcare Completed No outcome recorded
Phase 23 trials
Phase 2 NCT02386098 Jul 2015 → Jun 2017 HIV infectious disease ViiV Healthcare Terminated No outcome recorded
Phase 2 NCT02415595 May 2015 → May 2016 HIV infectious disease ViiV Healthcare Terminated No outcome recorded
Phase 2 NCT01803074 Apr 2013 → Nov 2014 HIV infectious disease ViiV Healthcare Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT02608918 Background Jan → May 2016 HIV infectious disease ViiV Healthcare Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 12 sources stand behind the page.

FieldValueCited text
Known as BMS 955176 “A single dose of \[14C\] BMS 955176 on Day 1 with ND placement 1 hour post dose to facilitate continuous bile collection though 8 hours post dose.” NCT02206711
11

NCT02576119

NCT02206711

NCT02095886

NCT02273947

NCT02608918

NCT02715479

NCT02578277

NCT02157467

NCT02415595

NCT02386098

NCT01803074

Known as GSK3532795 “A Phase 2b Randomized, Active-Controlled, Staged, Open-Label Trial to Investigate Safety and Efficacy of BMS-955176/GSK3532795 in Combination With Dolutegravir and Atazanavir...” NCT02386098
1

GSK3532795 (formerly known as BMS-955176) is a second-generation maturation inhibitor targeting a specific Gag cleavage site between capsid p24 and spacer peptide 1 of HIV-1.” PMID 30352054 Oct 2018

Action Inhibit “HIV Maturation Inhibitor” NCT02386098
Modality Other / unclassified “GSK3532795 (formerly known as BMS-955176) is a second-generation maturation inhibitor” PMID 30352054 Oct 2018
Route Oral “BMS-955176 5 mg solution by mouth once daily for 10 days” NCT01803074