Drugs / NEU-411
last change Jun 2025 re-read 3 minutes ago

NEU-411

Small molecule targets LRRK2 via inhibition

Developed for
Parkinson disease
Investigated by
Neuron23 Inc. · Qiagen Manchester Limited · Roche Diagnostic Ltd.

Trials 2

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT05755191 May 2023 → Jun 2024 — Neuron23 Inc. Completed No outcome recorded
Phase 21 trial
Phase 2 NCT06680830 Jan 2025 → Dec 2027 expected Parkinson disease Neuron23 Inc. Recruiting No outcome recorded

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2025-03-24 Neuron23 Inc. Results Neuron23 to Present Phase 1 Healthy Volunteer Data of NEU-411, a Brain-penetrant LRRK2 Inhibitor, at AD/PD™ 2025 neuron23.com ↗
NEU-411 was well-tolerated; no serious adverse events were observed, and all adverse events were mild or moderate.

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as NEU-411 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05755191 ↗
1

NCT06680830 ↗

Action Inhibit “inhibitor of LRRK2 activity” NCT06680830 ↗
Modality Small molecule “small molecule inhibitor of LRRK2 activity” NCT06680830 ↗
Route Oral “orally administered NEU-411” NCT05755191 ↗
Target LRRK2 “inhibitor of LRRK2 activity” NCT06680830 ↗