Sodium Acetate

also known as C11-Sodium Acetate · E-262(I) · E262 · FEMA NO. 3024 · INS NO.262(I) · INS-262(I) · NSC-77459 · Sodium acetate (3h2o) · +6 more

Small molecule

Developed for: metabolic acidosis · subarachnoid hemorrhage · stroke disorder
Investigated by: Phoenix Molecular Imaging · Aga Khan University Hospital, Pakistan · Emory University · Michael C Roarke, MD

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	FREAMINE HBC 6.9%	—	1971-09-24	fda.gov ↗

Trials 5 · a red edge is where a trial was stopped

today

US approved 1971

NCT06545565 · Ph 3 NCT03262389 · Ph 2 NCT03204955 · Ph 1 NCT01530269 · Ph 2 NCT01304485 · Ph 2

1971197219731974197519761977197819791980198119821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 11 trial
Phase 1	NCT03204955	Jun 2017 → Sep 2018	acute kidney injury, subarachnoid hemorrhage	Emory University	Completed	No outcome recorded
Phase 23 trials
Phase 2	NCT03262389	Sep 2017 → Nov 2019	plasma cell myeloma	Michael C Roarke, MD	Completed	No outcome recorded
Phase 2	NCT01530269	Apr 2012 → Jan 2019	prostate adenocarcinoma	Phoenix Molecular Imaging	Completed	No outcome recorded
Phase 2	NCT01304485	Apr 2011 → Jan 2019	prostate cancer	Phoenix Molecular Imaging	Completed	No outcome recorded
Phase 31 trial
Phase 3	NCT06545565	Jul 2024 → May 2025 overdue	metabolic acidosis	Aga Khan University Hospital, Pakistan	Recruiting	No outcome recorded

Also used as a comparator or background therapy in 1 trial

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 2/3	NCT05869565 Comparator	Feb 2023 → Feb 2024	stroke disorder	Aga Khan University	Unknown	No outcome recorded

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

Field	Value	Cited text
Known as	Sodium Acetate	“Sodium chloride (0.9%) and sodium acetate (0.9%) mixture 3:1 ratio for 72 hours post symptom onset (60-72 hours post randomization” NCT05869565 ↗ 4 “Sodium Acetate” NCT06545565 ↗ NCT03204955 ↗ NCT06545565 ↗ NCT03262389 ↗
Known as	C11-Sodium Acetate	ClinicalTrials.gov intervention name — accepted as the source's own label NCT01530269 ↗
Known as	E-262(I)	ChEMBL registry synonym — accepted as the source's own label CHEMBL1354 ↗
Known as	E262	ChEMBL registry synonym — accepted as the source's own label CHEMBL1354 ↗
Known as	FEMA NO. 3024	ChEMBL registry synonym — accepted as the source's own label CHEMBL1354 ↗
Known as	INS NO.262(I)	ChEMBL registry synonym — accepted as the source's own label CHEMBL1354 ↗
Known as	INS-262(I)	ChEMBL registry synonym — accepted as the source's own label CHEMBL1354 ↗
Known as	NSC-77459	ChEMBL registry synonym — accepted as the source's own label CHEMBL1354 ↗
Known as	Sodium acetate (3h2o)	ChEMBL registry synonym — accepted as the source's own label CHEMBL1354 ↗
Known as	Sodium acetate 1-c-11	ChEMBL registry synonym — accepted as the source's own label CHEMBL1354 ↗
Known as	Sodium acetate anhydrous	ChEMBL registry synonym — accepted as the source's own label CHEMBL1354 ↗
Known as	Sodium Acetate C11	ClinicalTrials.gov intervention name — accepted as the source's own label NCT01304485 ↗
Known as	Sodium acetate component of procalamine	ChEMBL registry synonym — accepted as the source's own label CHEMBL1354 ↗
Known as	Sodium acetate hydrate	ChEMBL registry synonym — accepted as the source's own label CHEMBL1354 ↗
Known as	Sodium acetate trihydrate	ChEMBL registry synonym — accepted as the source's own label CHEMBL1354 ↗
Modality	Diagnostic / imaging agent	“Positron emission tomography using carbon-11 acetate (AC-PET)” NCT01530269 ↗
Modality	Small molecule	— CHEMBL1354 ↗
Route	Intravenous	“Sodium Acetate is a sterile, nonpyrogenic solution of Sodium Acetate intended as an alternative to sodium chloride to provide sodium ion in parenteral (IV) fluid therapy.” NCT03204955 ↗