St. John's Wort
Traditional medicine (herbal / TCM) targets CYP2C19, CYP3A4 via activation
Trials 23 · a red edge is where a trial was stopped
Also used as a comparator or background therapy in 1 trial
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2 | NCT00587860 Comparator | Feb 2006 → Jan 2008 | irritable bowel syndrome | Mayo Clinic | Completed | No outcome recorded |
Evidence & citations 13 cited values
Every value below carries the sentence it was read from. 26 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | St. John's wort | “The purpose of this study is to evaluate whether patients post PCI receiving clopidogrel who are carriers of at least one CYP 2C19 loss-of-function allele may achieve improved...” NCT01330589 ↗20“The purpose of this trial is to study the acute efficacy and safety of a standardized extract of the herb Hypericum perforatum (St. John's Wort), called hypericum for purposes...” NCT00005013 ↗ “This pilot study examined the effectiveness, safety, tolerability, and pharmacodynamics of Hypericum perforatum (St. John's wort) in the treatment of youths diagnosed with...” PMID 12874492 ↗ Aug 2003 “The purpose of this study is to evaluate the effects of a common herbal remedy, St. John's Wort, on the effectiveness of birth control pills.” NCT00026013 ↗ “Phase III Randomized Study of Hypericum Perforatum (St. John's Wort) Combined With Docetaxel in Patients With Unresectable Solid Tumors” NCT00041171 ↗ “St. John's Wort (Hypericum perforatum) orally or 4-6 weeks” NCT00131885 ↗ “St. John´s Wort (100 mg) Valerian Extract (50 mg)” NCT00782080 ↗ “Hypericum perforatum (St. John's wort)” NCT00118833 ↗ “Other: St John's Wort” NCT01726764 ↗ |
| Known as | H. perforatum | “OBJECTIVE: To test the efficacy and safety of a well-characterized H perforatum extract (LI-160) in major depressive disorder.” PMID 11939866 ↗ Apr 2002 |
| Known as | hypericum | “The purpose of this trial is to study the acute efficacy and safety of a standardized extract of the herb Hypericum perforatum (St. John's Wort), called hypericum for purposes...” NCT00005013 ↗ |
| Known as | Hypericum perforatum | “This pilot study examined the effectiveness, safety, tolerability, and pharmacodynamics of Hypericum perforatum (St. John's wort) in the treatment of youths diagnosed with...” PMID 12874492 ↗ Aug 200312“There has been considerable worldwide interest in St. John's Wort (SJW) (Hypericum perforatum) as a treatment of mild to moderate depression.” NCT00035412 ↗ “Extract of St. John's wort (SJW: Hypericum perforatum) has gained widespread popularity as an over-the-counter, natural antidepressant.” NCT00027014 ↗ “Phase III Randomized Study of Hypericum Perforatum (St. John's Wort) Combined With Docetaxel in Patients With Unresectable Solid Tumors” NCT00041171 ↗ “Determine the efficacy of Hypericum perforatum (St. John's wort) in alleviating hot flashes” NCT00110136 ↗ “St. John's Wort (Hypericum perforatum) orally or 4-6 weeks” NCT00131885 ↗ |
| Known as | LI-160 | “OBJECTIVE: To test the efficacy and safety of a well-characterized H perforatum extract (LI-160) in major depressive disorder.” PMID 11939866 ↗ Apr 20021“Forty patients will be randomized to either SJW (LI 160) or matching placebo.” NCT00035412 ↗ |
| Known as | SGJY, St.John's wort and acanthopanax senticosus combination | “TCM named as Shuganjieyu capsule (SGJY, St. John's wort and acanthopanax senticosus combination).” NCT01938859 ↗ |
| Known as | Shuganjieyu capsule | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01938859 ↗ |
| Known as | SJW | “The objective of the proposed study is to assess the efficacy of the herbal St. John's Wort (SJW) in the treatment of symptoms of obsessive-compulsive disorder (OCD).” NCT00035438 ↗2“There has been considerable worldwide interest in St. John's Wort (SJW) (Hypericum perforatum) as a treatment of mild to moderate depression.” NCT00035412 ↗ “Extract of St. John's wort (SJW: Hypericum perforatum) has gained widespread popularity as an over-the-counter, natural antidepressant.” NCT00027014 ↗ |
| Known as | St. John's wort oil | “Hypericum perforatum (St. John's wort oil, Zade Vital; Health&Fitness, Developed With Ege Üniversiesi Argefar)” NCT06839313 ↗ |
| Action | Activate | “SJW treatment may increase the activity of a transporter protein, named P-glycoprotein (Pgp), in the blood-brain barrier (BBB) that protects the brain from exposure to drugs...” NCT00027014 ↗ |
| Modality | Traditional medicine (herbal / TCM) | “common herbal remedy” NCT00026013 ↗ |
| Route | Oral | “Patients receive oral Hypericum perforatum three times daily on days 1-14 and docetaxel as in arm I.” NCT00041171 ↗ |
| Target | CYP3A4 | “induce previously induced CYP3A4 enzyme activity” NCT00006395 ↗ |