Drugs / rubitecan

Trials 21 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT00113113 Aug 2001 → ? neoplasm Astex Pharmaceuticals, Inc. Completed No outcome recorded
Phase 1 NCT00006047 Jun 2000 → Feb 2003 cancer of unknown primary site H. Lee Moffitt Cancer Center and Research Institute Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT00492141 Jun 2006 → May 2007 Ewing sarcoma M.D. Anderson Cancer Center Completed No outcome recorded
Phase 214 trials
Phase 2 NCT00250120 Apr 2003 → Mar 2007 cancer, lung disorder University of New Mexico Withdrawn No outcome recorded
Phase 2 NCT00250068 Apr 2003 → Dec 2007 cancer, lung disorder University of New Mexico Completed No outcome recorded
Phase 2 NCT00249990 Apr 2003 → Jul 2006 endometrial cancer, uterine corpus cancer University of New Mexico Completed No outcome recorded
Phase 2 NCT00006082 May 2000 → Aug 2002 lung cancer European Organisation for Research and Treatment of Cancer - EORTC Completed No outcome recorded
Phase 2 NCT00006230 May 2000 → Apr 2003 ovarian cancer European Organisation for Research and Treatment of Cancer - EORTC Completed No outcome recorded
Phase 2 NCT00006026 May 2000 → Oct 2001 renal pelvis/ureter urothelial carcinoma, urethra cancer, urinary bladder cancer European Organisation for Research and Treatment of Cancer - EORTC Completed No outcome recorded
Phase 2 NCT00005876 Apr 2000 → ? esophageal cancer, gastric cancer Astex Pharmaceuticals, Inc. Unknown No outcome recorded
Phase 2 NCT00005826 Mar → Sep 2000 central nervous system neoplasm European Organisation for Research and Treatment of Cancer - EORTC Completed No outcome recorded
Phase 2 NCT00005873 Sep 1999 → Apr 2004 breast cancer Astex Pharmaceuticals, Inc. Completed No outcome recorded
Phase 2 NCT00005877 Sep 1999 → ? colorectal cancer Astex Pharmaceuticals, Inc. Unknown No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT00113256 Feb 2005 → Feb 2006 malignant pancreatic neoplasm Astex Pharmaceuticals, Inc. Terminated No outcome recorded
Phase 33 trials
Phase 3 NCT00005870 Mar 1999 → ? pancreatic adenocarcinoma Astex Pharmaceuticals, Inc. Unknown No outcome recorded
Phase 3 NCT00005871 Nov 1998 → ? malignant pancreatic neoplasm Astex Pharmaceuticals, Inc. Unknown No outcome recorded
Phase 3 NCT00005869 Nov 1998 → ? malignant pancreatic neoplasm Astex Pharmaceuticals, Inc. Unknown No outcome recorded

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 21 sources stand behind the page.

FieldValueCited text
Known as rubitecan ClinicalTrials.gov intervention name — accepted as the source's own label NCT00006026
15

NCT00005874

NCT00005872

NCT00006230

NCT00005871

NCT00005870

NCT00005877

NCT00113256

NCT00113113

NCT00005869

NCT00006082

NCT00005876

NCT00005873

NCT00005826

NCT00006267

NCT00005875

Known as 9-NC “The 9-nitrocamptothecin (9-NC) derivative to be used in this study is insoluble in water, but has demonstrated potent antitumor effects in mice and antitumor effect in humans.” NCT00249990
3

“Open Label Phase II Study on RFS 2000 (9-Nitro-camptothecin, 9-NC) Administered as a "5 Days On-2 Days Off" Oral Treatment in Advanced Ovarian Cancer” NCT00006230

“Open Label Phase II Study on RFS 2000 (9-Nitro-Camptothecin, 9-NC) Administered as a "5 Days On-2 Days Off" Oral Treatment in Glioblastoma Multiforme” NCT00005826

“A Phase II Study of RFS 2000 (Rubitecan, 9-Nitro-Camptothecin, 9-NC) in Patients With Advanced Gastric Carcinoma” NCT00005876

Known as 9-Nitro-20 (S)- Camptothecin “The purposes of this study are: 1.1 To determine the efficacy of liposomal 9-Nitro-20 (S)-Camptothecin (L9NC) administered by aerosolization to patients with metastatic...” NCT00249990
2

“Study of Aerosolized Liposomal 9-Nitro-20 (S)- Camptothecin (L9NC)” NCT00250068

NCT00250120

Known as 9-Nitro-camptothecin “Open Label Phase II Study on RFS 2000 (9-Nitro-camptothecin, 9-NC) Administered as a "5 Days On-2 Days Off" Oral Treatment in Advanced Ovarian Cancer” NCT00006230
4

“Open Label Phase II Study on RFS 2000 (9-Nitro-Camptothecin, 9-NC) Administered as a "5 Days On-2 Days Off" Oral Treatment in Glioblastoma Multiforme” NCT00005826

“A Phase II Study of RFS 2000 (Rubitecan, 9-Nitro-Camptothecin, 9-NC) in Patients With Advanced Gastric Carcinoma” NCT00005876

NCT00250068

NCT00006047

Known as L9NC “The purposes of this study are: 1.1 To determine the efficacy of liposomal 9-Nitro-20 (S)-Camptothecin (L9NC) administered by aerosolization to patients with metastatic...” NCT00249990
3

“Study of Aerosolized Liposomal 9-Nitro-20 (S)- Camptothecin (L9NC)” NCT00250068

L9NC: Liposomal 9-Nitro-20 (S)-Camptothecin” NCT00250120

NCT00492141

Known as Liposomal 9-Nitro-20 (S)-Camptothecin “L9NC: Liposomal 9-Nitro-20 (S)-CamptothecinNCT00250120
Known as nitrocamptothecin “PURPOSE: Phase II trial to study the effectiveness of nitrocamptothecin in treating patients who have glioblastoma multiforme.” NCT00005826
1

“Arm I: Patients receive nitrocamptothecin orally on days 1-5.” NCT00005871

Known as Orathecin “Patients will be treated with gemcitabine and Orathecin (rubitecan) capsules to evaluate the current estimate of overall survival as a study endpoint prior to launching the...” NCT00113256
Known as RFS 2000 “Open Label Phase II Study on RFS 2000 (9-Nitro-camptothecin, 9-NC) Administered as a "5 Days On-2 Days Off" Oral Treatment in Advanced Ovarian Cancer” NCT00006230
3

“Open Label Phase II Study on RFS 2000 (9-Nitro-Camptothecin, 9-NC) Administered as a "5 Days On-2 Days Off" Oral Treatment in Glioblastoma Multiforme” NCT00005826

“A Phase II Study of RFS 2000 (Rubitecan, 9-Nitro-Camptothecin, 9-NC) in Patients With Advanced Gastric Carcinoma” NCT00005876

“Phase I Study of Rubitecan (RFS 2000) in the Treatment of Cancer Patients With Organ Dysfunction” NCT00113113

Action Inhibit “oral topoisomerase I inhibitor” NCT00006047
Route Oral “Patients receive nitrocamptothecin orally daily on days 1-5.” NCT00005826