Drugs / Ozone
last change 5 days ago re-read 2 minutes ago

Ozone

Other / unclassified

Developed for
chemotherapy-induced neuropathy · impacted teeth, multiple · ischemic disease · osteoarthritis, knee · alveolar periostitis · bone inflammation disease · carpal tunnel syndrome · chronic pain syndrome
+10 more · dentin sensitivity · interstitial cystitis · keratitis · neuropathy, painful · periapical periodontitis · piriformis syndrome · pneumonia · infectious disease with sepsis · lumbar disk disease · myofascial pain syndrome
Investigated by
Bernardino Clavo, MD, PhD · Canary Isles Institute for Health Research Foundation · Instituto de Salud Carlos III · Servicio Canario de Salud · Assiut University · Centers for International Business Education and Research
+24 more · Council of Gran Canaria · Red de Investigación en Servicios de Salud en Enfermedades Crónicas · Tanta University · Anhembi Morumbi University · Ankara City Hospital Bilkent · Batman University · Clinica Nuestra Senora del Rosario · Colegio Oficial de Médicos de Las Palmas · Complejo Hospitalario Universitario Insular Materno Infantil · Erzurum Regional Training & Research Hospital · Fundación DISA, Spain · Fundación Española del Dolor (FED) · Fundación MAPFRE Guanarteme · Humanitas Clinical and Research Center · Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta · Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna · Jelena Krunic · Karadeniz Technical University · Minia University · Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · São Paulo Research Foundation · University of L'Aquila · University of Las Palmas de Gran Canaria · University of Sao Paulo

Trials 19 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 23 trials
Phase 2 NCT05853523 Feb 2021 → Feb 2022 dentin sensitivity University of L'Aquila Completed No outcome recorded
Phase 2 NCT04789135 Mar → Sep 2020 interstitial cystitis Anhembi Morumbi University Unknown No outcome recorded
Phase 2 NCT00946634 Jan → Mar 2009 periapical periodontitis University of Sao Paulo Completed No outcome recorded
Phase 2/35 trials
Phase 2/3 NCT06799351 Feb 2025 → Dec 2029 expected chemotherapy-induced neuropathy Bernardino Clavo, MD, PhD Recruiting No outcome recorded
Phase 2/3 NCT06706544 Feb 2025 → Dec 2029 expected chemotherapy-induced neuropathy Bernardino Clavo, MD, PhD Recruiting No outcome recorded
Phase 2/3 NCT04299893 Nov 2020 → Sep 2027 expected chemotherapy-induced neuropathy, chronic pain syndrome, neuropathy, painful Bernardino Clavo, MD, PhD Recruiting No outcome recorded
Phase 2/3 NCT03660657 Feb → Nov 2020 ischemic disease Bernardino Clavo, MD, PhD Terminated No outcome recorded
Phase 2/3 NCT03876067 Apr 2019 → Mar 2022 ischemic disease Assiut University Unknown No outcome recorded
Phase 34 trials
Phase 3 NCT06802354 Dec 2024 → Dec 2025 impacted teeth, multiple Jelena Krunic Completed No outcome recorded
Phase 3 NCT05689996 Jan → Apr 2023 keratitis Assiut University Unknown No outcome recorded
Phase 3 NCT04426721 Jun 2020 → Dec 2021 osteoarthritis, knee Humanitas Clinical and Research Center Unknown No outcome recorded
Phase 3 NCT04370223 May → Oct 2020 pneumonia Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta Unknown No outcome recorded
Phase 41 trial
Phase 4 NCT05304884 Jun 2021 → Feb 2022 Erzurum Regional Training & Research Hospital Completed No outcome recorded
Phase not applicable6 trials
NCT07498998 Jul → Aug 2026 overdue carpal tunnel syndrome Tanta University Not yet recruiting No outcome recorded
NCT06130618 Sep 2023 → Mar 2024 piriformis syndrome Ankara City Hospital Bilkent Unknown No outcome recorded
NCT05875506 May → Aug 2023 alveolar periostitis, bone inflammation disease Minia University Completed No outcome recorded
NCT06909305 Oct 2022 → Oct 2023 osteoarthritis, knee Tanta University Completed No outcome recorded
NCT04420572 Mar → Jun 2021 Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey Completed No outcome recorded
NCT06900907 Mar → Aug 2017 impacted teeth, multiple Batman University Completed No outcome recorded
Also used as a comparator or background therapy in 7 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT00566007 Comparator Dec 2008 → Mar 2014 lumbar disk disease Kovacs Foundation Terminated No outcome recorded
Phase 41 trial
Phase 4 NCT02910765 Comparator Oct 2016 → Mar 2017 infectious disease with sepsis Assiut University Unknown No outcome recorded
Phase not applicable5 trials
NCT06133712 Comparator Nov 2023 → Dec 2025 overdue carpal tunnel syndrome Tanta University Recruiting No outcome recorded
NCT05318560 Comparator Jun → Sep 2022 myofascial pain syndrome Pamukkale University Unknown No outcome recorded
NCT05837494 Comparator Jun 2022 → May 2023 osteoarthritis, knee Tanta University Completed No outcome recorded
NCT05000463 Comparator Feb → Aug 2022 chronic pain syndrome Assiut University Unknown No outcome recorded
NCT03742466 Comparator Nov 2018 → Jul 2019 carpal tunnel syndrome, chronic pain syndrome, scleroderma Assiut University Completed No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 27 sources stand behind the page.

FieldValueCited text
Known as ozone Ozone injection” NCT06130618
25

NCT05853523

NCT05837494

NCT05689996

NCT06799351

NCT04299893

NCT04789135

NCT06133712

NCT03660657

NCT06900907

NCT03876067

NCT00566007

NCT05000463

NCT05875506

NCT04370223

NCT04420572

NCT02910765

NCT04426721

NCT05304884

NCT06706544

NCT03742466

NCT06802354

NCT00946634

NCT07498998

NCT06909305

NCT05318560

Known as Aqueous Ozone “Drug: Aqueous OzoneNCT00946634
Known as Gas ozone “Combination Product: Gas ozoneNCT05853523
Known as Ozone-Based Agent “Drug: Ozone-Based AgentNCT05689996
Known as Triatomic oxygen ChEMBL registry synonym — accepted as the source's own label CHEMBL2447938
Action Inhibit “At low doses, O3 reduces the synthesis of prostaglandins (PGS) by inhibiting prostaglandin endoperoxide synthase (PGHS2) and cyclooxygenase (COXs).” NCT04789135
Modality Other / unclassified “local ozone therapy” NCT03742466
Route Other “Infiltration of intradiscal ozone” NCT00566007