Drugs / Elecoglipron
last change 13 days ago re-read 8 days ago

Elecoglipron

also known as AZD5004
Developed for
type 2 diabetes mellitus · chronic kidney disease · obesity disorder · heart failure
Investigated by
AstraZeneca · Parexel

Trials 12

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT07723833 Jul → Nov 2026 expected — AstraZeneca Recruiting No outcome recorded
Phase 1 NCT07534592 Apr → Aug 2026 overdue — AstraZeneca Active not recruiting No outcome recorded
Phase 21 trial
Phase 2 NCT06579092 Oct 2024 → Nov 2025 obesity disorder AstraZeneca Completed No outcome recorded
Phase 39 trials
Phase 3 NCT07761117 Aug 2026 → Sep 2029 expected heart failure AstraZeneca Recruiting No outcome recorded
Phase 3 NCT07775404 Aug 2026 → Apr 2028 expected obesity disorder AstraZeneca Recruiting No outcome recorded
Phase 3 NCT07753993 Aug 2026 → Oct 2030 expected chronic kidney disease AstraZeneca Recruiting No outcome recorded
Phase 3 NCT07662044 Jul 2026 → Jul 2028 expected type 2 diabetes mellitus AstraZeneca Recruiting No outcome recorded
Phase 3 NCT07664553 Jul 2026 → May 2028 expected type 2 diabetes mellitus AstraZeneca Not yet recruiting No outcome recorded
Phase 3 NCT07662213 Jul 2026 → May 2028 expected type 2 diabetes mellitus AstraZeneca Recruiting No outcome recorded
Phase 3 NCT07662135 Jul 2026 → Jul 2028 expected chronic kidney disease, type 2 diabetes mellitus AstraZeneca Recruiting No outcome recorded
Phase 3 NCT07662109 Jul 2026 → Jul 2028 expected type 2 diabetes mellitus AstraZeneca Recruiting No outcome recorded
Phase 3 NCT07667803 Jun 2026 → Jul 2028 expected — AstraZeneca Recruiting No outcome recorded

News releases announcing trial results or a regulatory action · 2

DateIssuerRelease
2026-06-08 AstraZeneca Results Elecoglipron, an oral small molecule GLP-1 RA, moves to Phase III programme and unlocks next chapter in AstraZeneca’s cardiometabolic and kidney portfolio astrazeneca.com ↗
Weight loss in participants receiving elecoglipron did not plateau, reaching 11.8% at 36 weeks (75mg) versus 0.3% with placebo.
2026-02-10 Eccogene Results Eccogene Announces Positive Topline Results from Phase 1b Trial of Elecoglipron (AZD5004/ECC5004), an Oral GLP-1 Receptor Agonist, in Adult Participants Living with Obesity/Overweight, with or without Type 2 Diabetes in China eccogene.com ↗
The results demonstrated a safety and tolerability profile consistent with the GLP-1 receptor agonist (GLP-1RA) class.

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 12 sources stand behind the page.

FieldValueCited text
Known as Elecoglipron “Elecoglipron (AZD5004) is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered once daily without food or fluid restriction” PMID 42259337 ↗ Jun 2026
11

NCT07534592 ↗

NCT07664553 ↗

NCT07662135 ↗

NCT07761117 ↗

NCT07753993 ↗

NCT07775404 ↗

NCT07723833 ↗

NCT07662109 ↗

NCT07667803 ↗

NCT07662213 ↗

Show 1 more source

Known as AZD5004 “Elecoglipron (AZD5004) is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered once daily without food or fluid restriction” PMID 42259337 ↗ Jun 2026
Action Activate “GLP-1) receptor agonist” PMID 42259337 ↗ Jun 2026
Route Oral “Elecoglipron was administered as oral once-daily tablets” PMID 42259337 ↗ Jun 2026