Drugs / BT1718
Trials 1
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/2 | NCT03486730 | Jan 2018 → Nov 2023 | esophageal cancer, lung sarcoma, non-small cell lung carcinoma | Cancer Research UK | Completed | Met primary |
News releases announcing trial results or a regulatory action · 3
| Date | Issuer | Release |
|---|---|---|
| 2020-04-07 | BicycleTx Limited | Results Bicycle Therapeutics Announces Pipeline Progress Update bicycletherapeutics.com ↗
Phase I dose escalation completed for BT1718—RP2D established and preliminary signs of anti-tumor activity observed, including one partial response |
| 2019-09-28 | BicycleTx Limited | Results Bicycle Therapeutics Announces Presentation of Updated Data from Phase I/IIa Trial Evaluating BT1718 in Patients with Advanced Solid Tumors at ESMO 2019 Annual Congress bicycletherapeutics.com ↗
Early analysis of data shows stable disease in 54% of evaluable patients at eight weeks, across all cohorts of the all-comers Phase I escalation |
| 2019-08-08 | BicycleTx Limited | Results Bicycle Therapeutics Reports Second Quarter 2019 Financial Results and Provides Clinical Update bicycletherapeutics.com ↗
Today, Bicycle announced that in the 25 mg/m2 once weekly cohort, no dose limiting toxicities were observed, and the decision was made to continue with dose escalation. |
All press releases naming this drug 8 releases
Evidence & citations 4 cited values
Every value below carries the sentence it was read from. 1 source stands behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | BT1718 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03486730 ↗ |
| Action | Inhibit | “designed to target and inhibit the function of the protein 'membrane type 1 metalloproteinase' (MT1-MMP)” NCT03486730 ↗ |
| Modality | Other / unclassified | “BT1718 is a type of drug called a 'bicycle drug conjugate'” NCT03486730 ↗ |
| Route | Intravenous | “BT1718 intravenously twice a week” NCT03486730 ↗ |