Drugs / AZD8055
last change Apr 2016 re-read 3 minutes ago

AZD8055

also known as AZ-12600000

Small molecule targets MTOR via inhibition

Developed for
cancer · anaplastic astrocytoma · anaplastic oligodendroglioma · brain stem glioma · glioblastoma · hepatocellular carcinoma · lymphoma
Investigated by
AstraZeneca · National Cancer Institute (NCI)

Trials 5

20082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT01316809 Mar 2011 → Apr 2014 anaplastic astrocytoma, anaplastic oligodendroglioma, brain stem glioma, glioblastoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT00999882 Oct 2009 → Dec 2011 hepatocellular carcinoma AstraZeneca Completed No outcome recorded
Phase 1 NCT00973076 Aug 2009 → Dec 2010 cancer AstraZeneca Completed No outcome recorded
Phase 1 NCT00731263 Jul 2008 → Nov 2010 cancer AstraZeneca Completed No outcome recorded
Phase 1 NCT01194193 — cancer, lymphoma AstraZeneca Withdrawn No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as AZD8055 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00731263 ↗
4

NCT01194193 ↗

NCT01316809 ↗

NCT00973076 ↗

NCT00999882 ↗

Known as AZ-12600000 ChEMBL registry synonym — accepted as the source's own label CHEMBL1801204 ↗
Action Inhibit “Tor kinase inhibitor AZD8055” NCT00731263 ↗
Modality Small molecule — CHEMBL1801204 ↗
Route Oral “AZD8055 will be administered orally” NCT00973076 ↗
Target MTOR “a first-in-class dual mTORC1/2 inhibitor” PMID 22843211 ↗ Jul 2012