Drugs / Umbilical Cord Blood
last change Aug 2026 re-read 3 minutes ago

Umbilical Cord Blood

also known as Cord blood · UCB · HPC, Cord Blood · hUCB · UBC

Cell therapy

Developed for
aplastic anemia · acute myeloid leukemia · brain hypoxia - ischemia · ischemic stroke · plasma cell myeloma · cerebral palsy · hematopoietic and lymphoid cell neoplasm · Hodgkins lymphoma
+22 more · myelodysplastic syndrome · acute myelomonocytic leukemia M4 · apraxia · autism · autism spectrum disorder 1 · B-cell chronic lymphocytic leukemia · bone marrow disorder · bone marrow failure syndrome · chronic lymphocytic leukemia/small lymphocytic lymphoma · chronic myeloid leukemia · disease related to hematopoietic stem cell transplant · global developmental delay with or without impaired intellectual development · hydrocephalus · leukemia · neonatal anemia · stroke disorder · bronchopulmonary dysplasia · cerebrovascular disorder · necrotizing enterocolitis · newborn respiratory distress syndrome · retinopathy of prematurity · type 1 diabetes mellitus
Investigated by
Joanne Kurtzberg, MD · Guangzhou First People's Hospital · Jining First People's Hospital · Linyi People's Hospital · Shandong Qilu Stem Cells Engineering Co., Ltd. · Shandong University of Traditional Chinese Medicine
+83 more · Taian City Central Hospital · Affiliated Hospital of Jining Medical University · Air Force Hospital of Western War Zone · Assisi Foundation · BHI Therapeutic Sciences · Binzhou People's Hospital · Bundang CHA Hospital · Canadian Cancer Society (CCS) · Canadian Institutes of Health Research (CIHR) · Celgene Corporation · Children's Hospital Affiliated to Shandong University · China Spinal Cord Injury Network · Chinese University of Hong Kong · Dezhou People's Hospital · Emory University · First Affiliated Hospital Xi'an Jiaotong University · Gansu Provincial Hospital of Traditional Chinese Medicine (TCM) · Gansu Wuwei Tumor Hospital · Guangdong Provincial People's Hospital · Guangzhou General Hospital of Guangzhou Military Command · Harbin Hematology and Oncology Institute · Hopital de l'Enfant-Jesus · Institute of Hematology & Blood Diseases Hospital, China · Jiangxi Province Children's Hospital · Jiangxi Provincial People's Hopital · Jinan Military General Hospital · Jinhua Central Hospital · Jining Medical University · Kaifeng Central Hospital · Korea Evaluation Institute of Industrial Technology · Lanling People's Hospital · M.D. Anderson Cancer Center · Maisonneuve-Rosemont Hospital · Massachusetts General Hospital · MinYoung Kim, M.D. · Mononuclear Therapeutics Ltd. · Nanfang Hospital, Southern Medical University · National Heart, Lung, and Blood Institute (NHLBI) · New York Medical College · Peking University People's Hospital · Qingdao Hiser Medical Group · Qingdao University · Rizhao People's Hospital · Second Affiliated Hospital of Zhengzhou University · Shandong Cord Blood Bank · Shandong Province Third hospital · Shengjing Hospital · Shengli Oilfield Hospital · Southern Medical University, China · St. Jude Children's Research Hospital · St. Justine's Hospital · Stem Cell Network · StemCyte International, Ltd. · StemCyte, Inc. · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Sun Yat-sen University · Sung Kwang Medical Foundation · The Affiliated Hospital of Binzhou Medical College · The First Affiliated Hospital of Soochow University · The First People' s Hospital of Yunnan Province · The First People's Hospital of Jingzhou · The Hartwell Foundation · The Marcus Foundation · The Second Affiliated Hospital of Harbin Medical University · The Second Affiliated Hospital of Shandong First Medical University · Third Affiliated Hospital, Sun Yat-Sen University · Tianjin Medical University General Hospital · Tufts Medical Center · Vancouver General Hospital · Weifang Medical University · Weihai Central Hospital · Weihai Municipal Hospital · West Virginia University · Wuwei People's Hospital · all 89 on the full record

Trials 23

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT05577611 Aug 2022 → Dec 2024 acute myeloid leukemia Zhongnan Hospital Unknown No outcome recorded
Phase 1 NCT03735277 Mar 2021 → Jul 2022 ischemic stroke BHI Therapeutic Sciences Unknown No outcome recorded
Phase 1 NCT04687657 Feb 2021 → Feb 2024 acute myelomonocytic leukemia M4 First Affiliated Hospital Xi'an Jiaotong University Unknown No outcome recorded
Phase 1 NCT03352310 Apr 2018 → Jun 2020 brain hypoxia - ischemia, neonatal anemia Mononuclear Therapeutics Ltd. Unknown No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT05794425 Aug 2023 → Apr 2025 bone marrow failure syndrome Shandong Qilu Stem Cells Engineering Co., Ltd. Unknown No outcome recorded
Phase 1/2 NCT04013646 May 2019 → Nov 2020 stroke disorder Bundang CHA Hospital Unknown No outcome recorded
Phase 1/2 NCT02668315 Dec 2015 → Aug 2018 hematopoietic and lymphoid cell neoplasm Maisonneuve-Rosemont Hospital Completed No outcome recorded
Phase 29 trials · 2 missed
Phase 2 NCT06040476 Sep 2025 → Dec 2027 expected ischemic stroke StemCyte, Inc. Not yet recruiting No outcome recorded
Phase 2 NCT02434965 Dec 2019 → Jan 2021 brain hypoxia - ischemia New York Medical College Withdrawn No outcome recorded
Phase 2 NCT03004976 Mar 2017 → Jul 2020 brain injury, ischemic stroke Joanne Kurtzberg, MD Completed Missed primary
Phase 2 NCT02847182 Sep 2016 → Aug 2018 autism, autism spectrum disorder 1 Joanne Kurtzberg, MD Completed Missed primary
Phase 2 NCT01763099 Jan 2013 → Jan 2015 disease related to hematopoietic stem cell transplant, hematologic disorder Nanfang Hospital, Southern Medical University Unknown No outcome recorded
Phase 2 NCT01408563 Dec 2011 → Jun 2017 Hodgkins lymphoma, acute myeloid leukemia, chronic lymphocytic leukemia/small lymphocytic lymphoma, plasma cell myeloma Massachusetts General Hospital Completed No outcome recorded
Phase 2 NCT01328496 Jun 2011 → Oct 2016 disease related to transplantation, hematopoietic and lymphoid cell neoplasm St. Jude Children's Research Hospital Completed No outcome recorded
Phase 2 NCT00604201 May 2008 → Oct 2016 aplastic anemia, myelodysplastic syndrome National Heart, Lung, and Blood Institute (NHLBI) Completed No outcome recorded
Phase 2 NCT00676806 Jul 2005 → Jul 2013 aplastic anemia, leukemia, plasma cell myeloma Tufts Medical Center Terminated No outcome recorded Stop: Enrollment
Phase 31 trial
Phase 3 NCT05669079 Aug 2023 → Aug 2026 overdue — The First Affiliated Hospital of Soochow University Not yet recruiting No outcome recorded
Phase 41 trial
Phase 4 NCT02838992 Feb 2017 → Dec 2018 aplastic anemia Jinan Military General Hospital Unknown No outcome recorded
Phase not applicable4 trials
— NCT07201233 Nov 2025 → Nov 2027 expected bone marrow disorder Shandong Qilu Stem Cells Engineering Co., Ltd. Not yet recruiting No outcome recorded
— NCT01601158 May 2012 → Aug 2013 global developmental delay with or without impaired intellectual development MinYoung Kim, M.D. Completed No outcome recorded
— NCT01193660 May 2010 → Apr 2011 cerebral palsy Sung Kwang Medical Foundation Completed No outcome recorded
— NCT01768845 Feb 2009 → May 2019 B-cell chronic lymphocytic leukemia, Hodgkins lymphoma, acute myeloid leukemia, aplastic anemia +3 West Virginia University Completed No outcome recorded
Phase not stated1 trial
— NCT03327467 — apraxia, brain hypoxia - ischemia, cerebral palsy, hydrocephalus Joanne Kurtzberg, MD Available No outcome recorded
Comparator or background therapy4 trials
Phase 1 NCT02050971 Comparator Oct 2010 → Dec 2014 bronchopulmonary dysplasia, cerebrovascular disorder, necrotizing enterocolitis, neonatal anemia +2 Pomeranian Medical University Szczecin Unknown No outcome recorded
Phase 1/2 NCT00305344 Comparator Apr 2005 → May 2011 type 1 diabetes mellitus University of Florida Completed No outcome recorded
Phase 2 NCT01622556 Background Jan 2012 → Feb 2014 hematopoietic and lymphoid system neoplasm University of Virginia Terminated No outcome recorded
— NCT01962636 Background Dec 2016 → May 2026 Burkitt lymphoma, acute myeloid leukemia, chronic lymphocytic leukemia/small lymphocytic lymphoma, chronic myeloid leukemia +11 Masonic Cancer Center, University of Minnesota Terminated No outcome recorded

Press releases naming this drug 1 release

DateIssuerRelease
2021-01-13 Celularity Incorporated Celularity Announces Release of 100th Cord Blood Stem Cell Unit by its Lifebank Division celularity.com ↗

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 29 sources stand behind the page.

FieldValueCited text
Known as umbilical cord blood “Compared with peripheral blood / bone marrow hematopoietic stem cells, umbilical cord blood (UCB) hematopoietic stem cells have the advantages of rapid access, convenient...” NCT05577611 ↗
16

“The primary purpose of this protocol is to enable access to autologous (a person's own) or allogeneic (someone else's) umbilical cord blood infusion for children with various...” NCT03327467 ↗

NCT05669079 ↗

NCT01962636 ↗

NCT02050971 ↗

NCT05794425 ↗

NCT01622556 ↗

NCT00676806 ↗

NCT03004976 ↗

NCT01193660 ↗

NCT07201233 ↗

Show 6 more sources

Known as Cord blood “Cord Blood infusion will occur on day 0” NCT01328496 ↗
7

NCT02434965 ↗

NCT00305344 ↗

NCT01763099 ↗

NCT01408563 ↗

NCT02668315 ↗

NCT02838992 ↗

NCT02847182 ↗

Known as HPC, Cord Blood ClinicalTrials.gov intervention name — accepted as the source's own label NCT03735277 ↗
Known as hUCB ClinicalTrials.gov intervention name — accepted as the source's own label NCT06040476 ↗
Known as UBC “umbilical cord blood (UBC)” NCT01768845 ↗
Known as UCB “Umbilical cord blood (UCB) is collected following labor and is transfused intravenously within 48 hours after the birth.” NCT03352310 ↗
4

“followed by umbilical cord blood (UCB) infusion in elderly patients with AML.” PMID 31429724 ↗ Aug 2019

“unrelated umbilical cord blood (UCB)” NCT00604201 ↗

“umbilical cord blood (UCB)” NCT01768845 ↗

NCT05577611 ↗

Action Restore “can restore the bone marrow” NCT01768845 ↗
Modality Cell therapy “received a single intravenous infusion of autologous UCB cells” PMID 22011412 ↗ Oct 2011
Route Intravenous “single intravenous infusion of autologous UCB cells” PMID 22011412 ↗ Oct 2011