Drugs / PF-04523655
last change Nov 2013 re-read 2 minutes ago

PF-04523655

Small interfering RNA (siRNA) targets DDIT4

Developed for
age-related macular degeneration · diabetic macular edema
Investigated by
Quark Pharmaceuticals · Pfizer

Trials 4 · a red edge is where a trial was stopped

200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT00725686 Feb 2007 → Nov 2010 age-related macular degeneration Quark Pharmaceuticals Completed No outcome recorded
Phase 23 trials
Phase 2 NCT01445899 Feb 2012 → Nov 2013 choroidal neovascularization, diabetic macular edema Quark Pharmaceuticals Completed No outcome recorded
Phase 2 NCT00713518 Nov 2009 → Nov 2010 age-related macular degeneration Quark Pharmaceuticals Completed No outcome recorded
Phase 2 NCT00701181 Jun 2008 → Jan 2011 diabetic macular edema Quark Pharmaceuticals Terminated No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as PF-04523655 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00725686
3

NCT01445899

NCT00713518

NCT00701181

Modality Small interfering RNA (siRNA) “a 19-nucleotide methylated double stranded siRNA targeting the RTP801 gene” PMID 23074206 Nov 2012
Route Intravitreal “PF-04523655 intravitreal injections” PMID 23074206 Nov 2012
Target RTP801 “a 19-nucleotide methylated double stranded siRNA targeting the RTP801 gene” PMID 23074206 Nov 2012