Drugs / IPAFRICEPT
last change Dec 2017 re-read 2 minutes ago

IPAFRICEPT

also known as OMP-54F28

Protein / enzyme biologic targets FZD8 via inhibition

Developed for
cancer · hepatocellular carcinoma · malignant pancreatic neoplasm · ovarian cancer
Investigated by
OncoMed Pharmaceuticals, Inc. · Bayer

Trials 4 · a red edge is where a trial was stopped

201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT02092363 Jan 2014 → Oct 2017 ovarian cancer OncoMed Pharmaceuticals, Inc. Completed No outcome recorded
Phase 1 NCT02069145 Jan 2014 → May 2017 hepatocellular carcinoma OncoMed Pharmaceuticals, Inc. Completed No outcome recorded
Phase 1 NCT02050178 Nov 2013 → Jun 2017 malignant pancreatic neoplasm OncoMed Pharmaceuticals, Inc. Completed No outcome recorded
Phase 1 NCT01608867 Jun 2012 → Aug 2016 cancer OncoMed Pharmaceuticals, Inc. Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as IPAFRICEPT ChEMBL registry synonym — accepted as the source's own label CHEMBL3301577
Known as OMP-54F28 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02092363
3

NCT02069145

NCT02050178

NCT01608867

Action Inhibit “Frizzled-8 antagonist” CHEMBL3301577
Modality Protein / enzyme biologic CHEMBL3301577
Route Intravenous “10 mg/kg administered IV once every 3 weeks” NCT01608867
Target FZD8 “Frizzled-8 antagonist” CHEMBL3301577