Drugs / Protionamide
Protionamide
also known as
Prothionamide · Ektebin · NSC-758962 · Peteha · Protionamida · Protionamidum · PTH · Pto-Protionamide · +3 more
Trials 5
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT02128308 | Nov → Dec 2013 | — | Seoul National University Hospital | Completed | No outcome recorded |
| Phase 31 trial · 1 met primary | ||||||
| Phase 3 | NCT02409290 | Mar 2016 → May 2022 | multidrug-resistant tuberculosis | IUATLD, Inc | Completed | Met primary |
| Phase 43 trials | ||||||
| Phase 4 | NCT03830671 | Mar 2019 → Jun 2022 | multidrug-resistant tuberculosis | Beijing Chest Hospital | Completed | No outcome recorded |
| Phase 4 | NCT03561753 | Dec 2017 → Dec 2019 | pulmonary tuberculosis | Shanghai Pulmonary Hospital, Shanghai, China | Completed | No outcome recorded |
| Phase 4 | NCT03237182 | Jun 2017 → Dec 2022 | multidrug-resistant tuberculosis | Centre for the AIDS Programme of Research in South Africa | Terminated | No outcome recorded |
| Comparator or background therapy6 trials | ||||||
| Phase 3 | NCT06081361 Comparator | Dec 2023 → Oct 2026 expected | pulmonary tuberculosis, rifampicin-resistant tuberculosis | Beijing Chest Hospital | Active not recruiting | No outcome recorded |
| Phase 3 | NCT02975570 Comparator | Aug 2017 → Aug 2021 | multidrug-resistant tuberculosis | Boston University | Withdrawn | No outcome recorded Stop: Business |
| Phase 3 | NCT02120638 Comparator | Apr 2014 → Apr 2016 | multidrug-resistant tuberculosis | Huashan Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT05306223 Background | May 2022 → Aug 2025 | multidrug-resistant tuberculosis | Beijing Chest Hospital | Unknown | Met primary |
| Phase 4 | NCT03867136 Comparator | Jun 2020 → Aug 2024 | multidrug-resistant tuberculosis | Huashan Hospital | Completed | No outcome recorded |
| — | NCT03604848 Comparator | Aug 2018 → Aug 2024 | multidrug-resistant tuberculosis | Huashan Hospital | Unknown | No outcome recorded |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 12 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Protionamide | “The candidated drugs to be selected are:Cs-Cycloserine,Pto-Protionamide,Clr-Clarithromycin,PAS-sodium para-aminosalicylate,E-ethambutol,Bdq-Bedaquiline,Cfz-Clofazimine,Lzd-linezolid” NCT03830671 ↗ |
| Known as | Ektebin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1378024 ↗ |
| Known as | NSC-758962 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1378024 ↗ |
| Known as | Peteha | ChEMBL registry synonym — accepted as the source's own label CHEMBL1378024 ↗ |
| Known as | Prothionamide | “PRS regimen, which consists of Clofazimine (Cfz), Ethambutol (E), high dose Pyrazinamide (Z, high), and Prothionamide (Pto).” NCT03561753 ↗8“Prothionamide 33-50kg 500 mg daily, 51-70kg 750 daily, \>70kg 1000 mg daily” NCT03604848 ↗ “Prothionamide 33-50kg 500 mg daily, 51-70kg 750 daily, \>70kg 1000 mg daily” NCT02120638 ↗ “Prothionamide ≤50kg 500 mg daily, \>50kg 750mg daily” NCT03867136 ↗ “ethionamide, prothionamide, cycloserine, terizidone” NCT03237182 ↗ “Prothionamide(PTH) 250mg (125mg x 2 tab) bid” NCT02128308 ↗ “ethionamide (or prothionamide)” NCT02975570 ↗ |
| Known as | Protionamida | ChEMBL registry synonym — accepted as the source's own label CHEMBL1378024 ↗ |
| Known as | Protionamidum | ChEMBL registry synonym — accepted as the source's own label CHEMBL1378024 ↗ |
| Known as | PTH | “Prothionamide(PTH) 250mg (125mg x 2 tab) bid” NCT02128308 ↗ |
| Known as | Pto-Protionamide | “The candidated drugs to be selected are:Cs-Cycloserine,Pto-Protionamide,Clr-Clarithromycin,PAS-sodium para-aminosalicylate,E-ethambutol,Bdq-Bedaquiline,Cfz-Clofazimine,Lzd-linezolid” NCT03830671 ↗ |
| Known as | RP 9778 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1378024 ↗ |
| Known as | TH-1321 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1378024 ↗ |
| Known as | Trevintix | ChEMBL registry synonym — accepted as the source's own label CHEMBL1378024 ↗ |
| Modality | Small molecule | — CHEMBL1378024 ↗ |
| Route | Oral | “Regimen C is a 40-week all-oral regimen consisting of bedaquiline, clofazimine, ethambutol, levofloxacin, and pyrazinamide given for 40 weeks supplemented by isoniazid and...” NCT02409290 ↗ |