Drugs / Rondecabtagene autoleucel
last change Jan 2026 re-read 2 minutes ago

Rondecabtagene autoleucel

also known as ronde-cel · LYL314

Cell therapy targets CD19

Developed for
large B-cell lymphoma · diffuse large B-cell lymphoma · non-Hodgkin lymphoma
Investigated by
Lyell Immunopharma, Inc.

Trials 2 · a red edge is where a trial was stopped

2024202520262027202820292030
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT05826535 May 2023 → Dec 2028 expected large B-cell lymphoma, non-Hodgkin lymphoma Lyell Immunopharma, Inc. Recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT07188558 Jan 2026 → Dec 2029 expected diffuse large B-cell lymphoma, large B-cell lymphoma Lyell Immunopharma, Inc. Recruiting No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as Rondecabtagene autoleucel ClinicalTrials.gov intervention name — accepted as the source's own label NCT05826535
1

NCT07188558

Known as LYL314 “rondecabtagene autoleucel (ronde-cel) also known as LYL314, a dual-targeting chimeric antigen receptor (CAR) targeting cluster of differentiation (CD)19 and CD20 in...” NCT05826535
Known as ronde-cel “rondecabtagene autoleucel (ronde-cel) also known as LYL314, a dual-targeting chimeric antigen receptor (CAR) targeting cluster of differentiation (CD)19 and CD20 in...” NCT05826535
1

“This Phase 3 study compares rondecabtagene autoleucel (ronde-cel, a dual-targeting CD19/CD20 CAR T-cell therapy)” NCT07188558

Modality Cell therapy “CAR T-cell therapyNCT05826535
Route Intravenous “single administration of CAR transduced autologous T-cells administered intravenously” NCT05826535
Target CD19 “dual-targeting CD19/CD20 CAR T-cell product candidate” NCT07188558