Drugs / Ezurpimtrostat
last change Mar 2024 re-read 2 minutes ago

Ezurpimtrostat

also known as GNS561 · Ezurpimtrostat (GNS561)

Small molecule

Developed for
hepatocellular carcinoma · cholangiocarcinoma · COVID-19 · intrahepatic cholangiocarcinoma
Investigated by
Genoscience Pharma · Genfit · University Hospital, Grenoble

Trials 5 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT05353894 May → Nov 2022 liver cancer Genoscience Pharma Unknown No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT05874414 Aug 2023 → Dec 2027 expected cholangiocarcinoma Genfit Recruiting No outcome recorded
Phase 1/2 NCT03316222 Apr 2018 → Jan 2021 hepatocellular carcinoma, intrahepatic cholangiocarcinoma Genoscience Pharma Terminated No outcome recorded
Phase 22 trials
Phase 2 NCT05448677 Dec 2022 → Mar 2024 hepatocellular carcinoma University Hospital, Grenoble Terminated No outcome recorded
Phase 2 NCT04637828 Nov 2020 → Jul 2021 COVID-19 Genoscience Pharma Unknown No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Ezurpimtrostat “GNS561/Ezurpimtrostat is a first-in-class, orally bioavailable, small molecule that blocks cancer cell proliferation by inhibiting late-stage autophagy and dose-dependent...” PMID 35949290 Feb 2022
1

NCT05448677

Known as Ezurpimtrostat (GNS561) Ezurpimtrostat (GNS561)NCT05874414
Known as GNS561 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04637828
3

NCT03316222

NCT05353894

NCT05874414

Modality Small molecule “a first-in-class, orally bioavailable, small moleculePMID 35949290 Feb 2022
Route Oral “single oral intake 3 times a week” PMID 35949290 Feb 2022