drugset
Drugs / Encaleret
last change Jan 2026 re-read 2 minutes ago

Encaleret

also known as MK-5442 · ENCALERET SULFATE · Jit-305 · JTT-305

Small molecule

Developed for
autosomal dominant hypocalcemia 1 · osteoporosis · postmenopausal osteoporosis · secondary hypoparathyroidism due to impaired parathormon secretion
Investigated by
Calcilytix Therapeutics, Inc., a BridgeBio company · Merck Sharp & Dohme LLC · National Institute of Dental and Craniofacial Research (NIDCR)

Trials 6 · a red edge is where a trial was stopped

today NCT07080385 · Ph 2/3 NCT05735015 · Ph 2 NCT05680818 · Ph 3 NCT04581629 · Ph 2 NCT00996801 · Ph 2 NCT00960934 · Ph 2
20102011201220132014201520162017201820192020202120222023202420252026202720282029
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 24 trials
Phase 2 NCT05735015 Sep 2023 → May 2025 secondary hypoparathyroidism due to impaired parathormon secretion National Institute of Dental and Craniofacial Research (NIDCR) Completed No outcome recorded
Phase 2 NCT04581629 Sep 2020 → Sep 2023 autosomal dominant hypocalcemia 1 Calcilytix Therapeutics, Inc., a BridgeBio company Completed No outcome recorded
Phase 2 NCT00996801 Nov 2009 → Jun 2011 postmenopausal osteoporosis Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 2 NCT00960934 Oct 2009 → Dec 2010 osteoporosis Merck Sharp & Dohme LLC Terminated No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT07080385 Jan 2026 → Dec 2028 expected autosomal dominant hypocalcemia 1 Calcilytix Therapeutics, Inc., a BridgeBio company Recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT05680818 Jan 2023 → Aug 2025 overdue autosomal dominant hypocalcemia 1 Calcilytix Therapeutics, Inc., a BridgeBio company Active not recruiting No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as Encaleret ClinicalTrials.gov intervention name — accepted as the source's own label NCT05680818 ↗
3

NCT04581629 ↗

NCT05735015 ↗

NCT07080385 ↗
Known as ENCALERET SULFATE ChEMBL registry synonym — accepted as the source's own label CHEMBL1672973 ↗
Known as Jit-305 ChEMBL registry synonym — accepted as the source's own label CHEMBL1672973 ↗
Known as JTT-305 ChEMBL registry synonym — accepted as the source's own label CHEMBL1672973 ↗
Known as MK-5442 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00996801 ↗
1

NCT00960934 ↗
Action Inhibit “calcium-sensing receptor antagonist” PMID 25166719 ↗ Aug 2014
Modality Small molecule — CHEMBL1672973 ↗
Route Oral “administered daily oral MK-5442” PMID 25166719 ↗ Aug 2014