Drugs / LSALT Peptide
last change May 2024 re-read 2 minutes ago

LSALT Peptide

also known as Metablok

Peptide targets DPEP1 via inhibition

Developed for
COVID-19 · acute kidney injury · acute respiratory distress syndrome
Investigated by
Arch Biopartners Inc. · AbbVie · Apotex Inc. · Sunnybrook Health Sciences Centre · University of British Columbia · World Health Organization

Trials 2 · a red edge is where a trial was stopped

202120222023202420252026
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT04402957 Oct 2020 → May 2021 COVID-19, acute kidney injury, acute respiratory distress syndrome, severe acute respiratory syndrome Arch Biopartners Inc. Completed No outcome recorded
Phase 31 trial
Phase 3 NCT04330690 Mar 2020 → Mar 2024 COVID-19 Sunnybrook Health Sciences Centre Unknown No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as LSALT Peptide ClinicalTrials.gov intervention name — accepted as the source's own label NCT04330690
1

NCT04402957

Known as Metablok ChEMBL registry synonym — accepted as the source's own label CHEMBL5314991
Action Inhibit “through the direct inhibition of leukocyte adhesion to DPEP-1” NCT04402957
Modality Peptide “LSALT, a peptide drug with the sequence NH3-LSALTPSPSWLKYKAL-COOH” NCT04402957
Route Intravenous “5 mg , 2 hour IV infusion once daily for up to 14 consecutive days” NCT04330690
Target DPEP1 “binds to dipeptidase-1 (DPEP-1)” NCT04402957