Drugs / bepranemab
last change Aug 2025 re-read 3 minutes ago

bepranemab

also known as UCB0107

Monoclonal antibody targets MAPT via inhibition

Developed for
progressive supranuclear palsy · Alzheimer disease
Investigated by
UCB Biopharma SRL · UCB Biopharma S.P.R.L.

Trials 5

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT04658199 Nov 2020 → Dec 2027 expected progressive supranuclear palsy UCB Biopharma SRL Active not recruiting No outcome recorded
Phase 1 NCT04185415 Dec 2019 → Nov 2021 progressive supranuclear palsy UCB Biopharma SRL Completed No outcome recorded
Phase 1 NCT03605082 Jul 2018 → Mar 2019 — UCB Biopharma S.P.R.L. Completed No outcome recorded
Phase 1 NCT03464227 Feb → Dec 2018 — UCB Biopharma S.P.R.L. Completed No outcome recorded
Phase 21 trial
Phase 2 NCT04867616 Jun 2021 → May 2024 Alzheimer disease UCB Biopharma SRL Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as bepranemab “UCB0107 (bepranemab)” NCT04658199 ↗
2

NCT04185415 ↗

NCT04867616 ↗

Known as UCB0107 “A Study to Test the Efficacy, Safety, and Tolerability of Bepranemab (UCB0107) in Patients With Mild Cognitive Impairment or Mild Alzheimer's Disease (AD)” NCT04867616 ↗
3

NCT04658199 ↗

NCT03605082 ↗

NCT03464227 ↗

Action Inhibit “Microtubule-associated protein tau inhibitor” CHEMBL4594612 ↗
Modality Monoclonal antibody — CHEMBL4594612 ↗
Route Intravenous “Route of administration: intravenous use” NCT03464227 ↗
Target MAPT “Microtubule-associated protein tau inhibitor” CHEMBL4594612 ↗