Drugs / M1095
last change May 2026 re-read 2 minutes ago

M1095

also known as Sonelokimab · ALX-0761 · MSB0010841 · SLK

Protein / enzyme biologic targets IL17A, IL17F via inhibition

Developed for
hidradenitis suppurativa · psoriatic arthritis · psoriasis
Investigated by
MoonLake Immunotherapeutics AG · Avillion LLP · Bond Avillion 2 Development LP · Merck KGaA, Darmstadt, Germany

Trials 11 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT02156466 Aug 2014 → Aug 2015 psoriasis Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 23 trials
Phase 2 NCT05640245 Dec 2022 → Sep 2023 psoriatic arthritis MoonLake Immunotherapeutics AG Completed No outcome recorded
Phase 2 NCT05322473 Apr 2022 → May 2023 hidradenitis suppurativa MoonLake Immunotherapeutics AG Completed No outcome recorded
Phase 2 NCT03384745 Jul 2018 → Jun 2019 psoriasis Bond Avillion 2 Development LP Completed No outcome recorded
Phase 37 trials
Phase 3 NCT07223138 Nov 2025 → Feb 2028 expected psoriatic arthritis MoonLake Immunotherapeutics AG Enrolling by invitation No outcome recorded
Phase 3 NCT07007637 Jun 2025 → Jun 2028 expected hidradenitis suppurativa MoonLake Immunotherapeutics AG Enrolling by invitation No outcome recorded
Phase 3 NCT06768671 Dec 2024 → Sep 2026 expected hidradenitis suppurativa MoonLake Immunotherapeutics AG Active not recruiting No outcome recorded
Phase 3 NCT06641089 Oct 2024 → Jan 2027 expected psoriatic arthritis MoonLake Immunotherapeutics AG Recruiting No outcome recorded
Phase 3 NCT06641076 Oct 2024 → Feb 2027 expected psoriatic arthritis MoonLake Immunotherapeutics AG Active not recruiting No outcome recorded
Phase 3 NCT06411899 May 2024 → Sep 2025 hidradenitis suppurativa MoonLake Immunotherapeutics AG Completed No outcome recorded
Phase 3 NCT06411379 May 2024 → Aug 2025 hidradenitis suppurativa MoonLake Immunotherapeutics AG Completed No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 13 sources stand behind the page.

FieldValueCited text
Known as M1095 “Sonelokimab (M1095)” NCT05322473
1

NCT03384745

Known as ALX-0761 ChEMBL registry synonym — accepted as the source's own label CHEMBL4298023
Known as MSB0010841 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02156466
Known as SLK “trial of sonelokimab (SLK), a nanobody that binds with a similarly high affinity to IL-17A and IL-17F, inhibiting all dimers.” PMID 41053449 Oct 2025
Known as Sonelokimab ClinicalTrials.gov intervention name — accepted as the source's own label NCT06768671
8

NCT07007637

NCT07223138

NCT05322473

NCT06411379

NCT06641089

NCT06411899

NCT06641076

NCT05640245

Action Inhibit “Interleukin-17F inhibitor” CHEMBL4298023
2

“Interleukin 17A inhibitor” CHEMBL4298023

“Anti- IL-17A/F Nanobody” NCT02156466

Modality Protein / enzyme biologic “MSB0010841(Anti- IL-17A/F Nanobody)” NCT02156466
Route Subcutaneous “as SC injection” NCT02156466
Target IL17A “Interleukin 17A inhibitor” CHEMBL4298023
Target IL17F “Interleukin-17F inhibitor” CHEMBL4298023