Drugs / AAVrh.10hFXN
Trials 1
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1 | NCT05302271 | Feb 2022 → Dec 2028 expected | Friedreich ataxia, cardiomyopathy | Weill Medical College of Cornell University | Recruiting | No outcome recorded |
News releases announcing trial results or a regulatory action · 2
| Date | Issuer | Release |
|---|---|---|
| 2024-07-15 | Lexeo Therapeutics | Results Lexeo Therapeutics Announces Positive Interim Phase 1/2 Clinical Data of LX2006 for the Treatment of Friedreich Ataxia Cardiomyopathy lexeotx.com ↗ |
| 2022-05-03 | Lexeo Therapeutics | Results LEXEO Therapeutics Announces Data Presentations at the 25th American Society of Gene & Cell Therapy (ASGCT) Annual Meeting lexeotx.com ↗
This preclinical study identified a therapeutically effective dose of AAVrh10 expressing human FXN (AAVrh.10hFXN) that has the potential to be clinically relevant for the treatment of the cardiac manifestations of FA. |
All press releases naming this drug 2 releases
| Date | Issuer | Release |
|---|---|---|
| 2024-07-15 | Lexeo Therapeutics | Lexeo Therapeutics Announces Positive Interim Phase 1/2 Clinical Data of LX2006 for the Treatment of Friedreich Ataxia Cardiomyopathy lexeotx.com ↗ |
| 2022-05-03 | Lexeo Therapeutics | LEXEO Therapeutics Announces Data Presentations at the 25th American Society of Gene & Cell Therapy (ASGCT) Annual Meeting lexeotx.com ↗ |
Evidence & citations 5 cited values
Every value below carries the sentence it was read from. 1 source stands behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | AAVrh.10hFXN | ClinicalTrials.gov intervention name — accepted as the source's own label NCT05302271 ↗ |
| Action | Restore | “vector expressing the cDNA coding for human FXN” NCT05302271 ↗ |
| Modality | Gene therapy (AAV / viral vector) | “serotype rh.10 adeno-associated virus (AAV) gene transfer vector” NCT05302271 ↗ |
| Route | Intravenous | “AAVrh.10hFXN will be administered intravenously.” NCT05302271 ↗ |
| Target | FXN | “AAVrh.10hFXN, serotype rh.10 adeno-associated virus (AAV) gene transfer vector expressing the cDNA coding for human FXN” NCT05302271 ↗ |