Drugs / Obicetrapib

Trials 25 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT06250205 Feb → Apr 2024 NewAmsterdam Pharma Completed No outcome recorded
Phase 1 NCT06050291 Jan → Apr 2024 NewAmsterdam Pharma Completed No outcome recorded
Phase 1 NCT05972278 Dec 2023 → Sep 2024 overdue NewAmsterdam Pharma Active not recruiting No outcome recorded
Phase 1 NCT06048302 Nov 2023 → Mar 2024 NewAmsterdam Pharma Completed No outcome recorded
Phase 1 NCT02408055 Jun → Aug 2015 hyperlipidemia Xention Ltd Completed No outcome recorded
Phase 1 NCT02241759 Aug → Nov 2014 hyperlipidemia Xention Ltd Completed No outcome recorded
Phase 1 NCT02124954 May → Jul 2014 Xention Ltd Completed No outcome recorded
Phase 1 NCT01879020 Aug 2009 → Jun 2010 hyperlipidemia Tanabe Pharma Corporation Completed No outcome recorded
Phase 1 NCT01878474 Mar 2008 → Jun 2009 hyperlipidemia Tanabe Pharma Corporation Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT02241772 Sep 2014 → Jan 2015 lipoprotein, variant of beta Xention Ltd Completed No outcome recorded
Phase 28 trials
Phase 2 NCT06982508 Sep 2025 → Sep 2026 expected NewAmsterdam Pharma Recruiting No outcome recorded
Phase 2 NCT06496243 Dec 2024 → Nov 2026 expected hyperlipidemia NewAmsterdam Pharma Recruiting No outcome recorded
Phase 2 NCT05421078 Jun 2022 → Mar 2023 hyperlipidemia NewAmsterdam Pharma Completed No outcome recorded
Phase 2 NCT05266586 Mar → Aug 2022 hyperlipidemia NewAmsterdam Pharma Completed No outcome recorded
Phase 2 NCT05161715 Jan 2022 → May 2023 Alzheimer disease NewAmsterdam Pharma Completed No outcome recorded
Phase 2 NCT04770389 Feb → May 2021 hyperlipidemia, hyperlipoproteinemia NewAmsterdam Pharma Completed No outcome recorded
Phase 2 NCT04753606 Feb → May 2021 hyperlipidemia, hyperlipoproteinemia, low density lipoprotein cholesterol, mild elevation of NewAmsterdam Pharma Completed No outcome recorded
Phase 2 NCT01970215 Aug 2013 → Jul 2014 hyperlipidemia Xention Ltd Completed No outcome recorded
Phase 37 trials
Phase 3 NCT07614958 May 2026 → Jan 2027 expected hyperlipidemia, combined, 2 A. Menarini International Licensing S.A. Recruiting No outcome recorded
Phase 3 NCT07219602 Dec 2025 → Mar 2028 expected hyperlipidemia, metabolic syndrome X, type 2 diabetes mellitus NewAmsterdam Pharma Recruiting No outcome recorded
Phase 3 NCT06305559 May 2024 → Nov 2027 expected atherosclerosis, coronary artery disorder, hyperlipidemia NewAmsterdam Pharma Active not recruiting No outcome recorded
Phase 3 NCT06005597 Mar → Sep 2024 atherosclerotic cardiovascular disease, familial hypercholesterolemia NewAmsterdam Pharma Completed No outcome recorded
Phase 3 NCT05425745 Jul 2022 → May 2024 familial hypercholesterolemia, low density lipoprotein cholesterol, mild elevation of NewAmsterdam Pharma Completed No outcome recorded
Phase 3 NCT05202509 Feb 2022 → Nov 2026 expected atherosclerotic cardiovascular disease NewAmsterdam Pharma Active not recruiting No outcome recorded
Phase 3 NCT05142722 Dec 2021 → Sep 2024 atherosclerotic cardiovascular disease, familial hypercholesterolemia NewAmsterdam Pharma Completed No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT06547359 Comparator Oct → Nov 2024 NewAmsterdam Pharma Completed No outcome recorded
Phase 1 NCT06081166 Comparator Nov → Dec 2023 NewAmsterdam Pharma Completed No outcome recorded

Evidence & citations 12 cited values

Every value below carries the sentence it was read from. 31 sources stand behind the page.

FieldValueCited text
Known as obicetrapib “Participants will receive a single Obicetrapib/Ezetimibe, 10 mg/10 mg FDC Tablet in a fed condition on Day 1 of treatment followed by a single Obicetrapib/Ezetimibe, 10 mg/10...” NCT06050291
20

“Patients were randomly assigned to one of nine groups using various combinations of the CETP inhibitor TA-8995 (obicetrapib), statin therapy, and placebo.” PMID 36307922 Feb 2023

NCT06250205

NCT04770389

NCT05142722

NCT05266586

NCT05161715

NCT06305559

NCT05421078

NCT07614958

NCT07219602

NCT06496243

NCT04753606

NCT06048302

NCT06982508

NCT05425745

NCT06547359

NCT05972278

NCT06005597

NCT06081166

NCT05202509

Known as AMG-899 ChEMBL registry synonym — accepted as the source's own label CHEMBL3785197
Known as CASA ChEMBL registry synonym — accepted as the source's own label CHEMBL3785197
Known as DEZ-001 ChEMBL registry synonym — accepted as the source's own label CHEMBL3785197
Known as OBI obicetrapib (OBI) compared to bempedoic acid (BPA)” NCT07614958
Known as OBICETRAPIB CALCIUM ChEMBL registry synonym — accepted as the source's own label CHEMBL3785197
Known as TA-8995 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01878474
6

NCT02241759

NCT02124954

NCT02241772

NCT01879020

NCT02408055

NCT01970215

Known as TA-8995 CALCIUM ChEMBL registry synonym — accepted as the source's own label CHEMBL3785197
Action Inhibit “TA-8995 is a potent inhibitor of cholesteryl ester transfer protein (CETP)” PMID 27678430 Jun 2016
Modality Small molecule CHEMBL3785197
Route Oral “Single oral dose of 150mg TA-8995” NCT02241759
Target CETP “the cholesteryl ester transfer protein (CETP) inhibitor drug obicetrapib” PMID 35953719 Aug 2022