Drugs / bleselumab
last change Jul 2024 re-read 2 minutes ago

bleselumab

also known as ASKP1240

Monoclonal antibody targets CD40 via inhibition

Developed for
primary focal segmental glomerulosclerosis · psoriasis
Investigated by
Kyowa Kirin, Inc. · Astellas Pharma Global Development, Inc. · Astellas Pharma Inc

Trials 5 · a red edge is where a trial was stopped

20112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT01582399 Feb → Sep 2012 Astellas Pharma Global Development, Inc. Completed No outcome recorded
Phase 1 NCT01279538 Nov 2010 → Jan 2012 Astellas Pharma Inc Completed No outcome recorded
Phase 23 trials
Phase 2 NCT02921789 May 2017 → Dec 2020 primary focal segmental glomerulosclerosis Astellas Pharma Global Development, Inc. Completed No outcome recorded
Phase 2 NCT01780844 Mar 2013 → Jun 2014 Astellas Pharma Global Development, Inc. Completed No outcome recorded
Phase 2 NCT01585233 Apr 2012 → Jun 2014 psoriasis Astellas Pharma Global Development, Inc. Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as bleselumab “anti-CD40 monoclonal antibody bleselumab (ASKP1240)” PMID 31509331 Oct 2019
2

NCT02921789

NCT01279538

Known as ASKP1240 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01780844
2

NCT01582399

NCT01585233

Action Inhibit “anti-CD40 antagonistic monoclonal antibody” PMID 39042770 Jul 2024
Modality Monoclonal antibody “a fully human, anti-CD40 monoclonal antibodyPMID 31397943 Sep 2019
Route Intravenous Intravenous (IV) infusion” NCT01279538
Target CD40 “anti-CD40 monoclonal antibody” PMID 31397943 Sep 2019