Drugs / autologous bone marrow mononuclear cells
last change Jun 2026 re-read 2 minutes ago

autologous bone marrow mononuclear cells

Cell therapy

Developed for
cerebral palsy · spinal cord injury · traumatic brain injury · autism · cerebellar ataxia · chronic renal failure syndrome · compartment syndrome · diabetes mellitus
+15 more · disease related to hematopoietic stem cell transplant · encephalitis · female infertility of uterine origin · hepatitis C induced liver cirrhosis · intracranial embolism · ischemic stroke · limb ischemia · meningitis · myocardial infarction · myocardial ischemia · retinitis pigmentosa · stroke disorder · systolic heart failure · type 1 diabetes mellitus · ulcer of lower limbs
Investigated by
Neurogen Brain and Spine Institute · Vinmec Research Institute of Stem Cell and Gene Technology · Chaitanya Hospital, Pune · The University of Texas Health Science Center, Houston · Vinmec Healthcare System · Oswaldo Cruz Foundation
+29 more · Ankara University · Ankara Yildirim Beyazıt University · Atigen-Cell and Tissue Center · BioCardia, Inc. · CellPraxis Bioengenharia Ltda. · Cellonis Biotechnology Co. Ltd. · Chinese Academy of Medical Sciences, Fuwai Hospital · Chinese Academy of Sciences · Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. · Cryopraxis Criobiologia Ltda. · Dr. Sami Ulus Children's Hospital · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Federal University of Bahia · Federal University of Rio de Janeiro · Federal University of São Paulo · Financiadora de Estudos e Projetos · Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) · Hacettepe University · Hebei Medical University · Institute of Biomedical Research and Innovation, Kobe, Hyogo, Japan · National Cerebral and Cardiovascular Center, Japan · National Institute of Neurological Disorders and Stroke (NINDS) · National Institutes of Health (NIH) · Oregon Health and Science University · Turkiye Yuksek Ihtisas Education and Research Hospital · University of Edinburgh · University of South Florida · Vinmec Health Care System (Vingroup Joint Stock Company) · Yali Hu

Trials 29 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 111 trials
Phase 1 NCT03880656 Dec 2019 → Dec 2025 overdue compartment syndrome Oregon Health and Science University Active not recruiting No outcome recorded
Phase 1 NCT05472428 Jul 2016 → Dec 2020 Vinmec Research Institute of Stem Cell and Gene Technology Completed No outcome recorded
Phase 1 NCT02241395 Aug 2013 → Jun 2018 cerebral palsy Neurogen Brain and Spine Institute Withdrawn No outcome recorded
Phase 1 NCT01937416 Jan 2012 → Sep 2013 diabetes mellitus, limb ischemia Hebei Medical University Unknown No outcome recorded
Phase 1 NCT02245724 Sep 2011 → Mar 2016 Neurogen Brain and Spine Institute Withdrawn No outcome recorded
Phase 1 NCT01143168 Aug 2010 → Aug 2011 type 1 diabetes mellitus Cellonis Biotechnology Co. Ltd. Unknown No outcome recorded
Phase 1 NCT00859014 Jan 2009 → Nov 2013 ischemic stroke The University of Texas Health Science Center, Houston Completed No outcome recorded
Phase 1 NCT00832247 Jan 2009 → Apr 2010 hepatitis C induced liver cirrhosis Federal University of Rio de Janeiro Unknown No outcome recorded
Phase 1 NCT02027246 Dec 2008 → Aug 2012 spinal cord injury Neurogen Brain and Spine Institute Withdrawn No outcome recorded
Phase 1 NCT02065778 Dec 2008 → Jul 2013 stroke disorder Neurogen Brain and Spine Institute Withdrawn No outcome recorded
Phase 1/28 trials
Phase 1/2 NCT04233892 Apr 2020 → Dec 2022 female infertility of uterine origin Yali Hu Unknown No outcome recorded
Phase 1/2 NCT02323477 Feb 2015 → Sep 2018 myocardial ischemia Ankara University Terminated No outcome recorded
Phase 1/2 NCT01958177 Sep 2014 → Dec 2016 cerebellar ataxia Chaitanya Hospital, Pune Unknown No outcome recorded
Phase 1/2 NCT01914913 Sep 2014 → Nov 2016 retinitis pigmentosa Chaitanya Hospital, Pune Unknown No outcome recorded
Phase 1/2 NCT01876017 Sep 2014 → Nov 2016 chronic renal failure syndrome Chaitanya Hospital, Pune Unknown No outcome recorded
Phase 1/2 NCT04080921 Jun 2014 → Jun 2019 encephalitis, meningitis Vinmec Research Institute of Stem Cell and Gene Technology Completed No outcome recorded
Phase 1/2 NCT01575470 Mar 2012 → May 2015 traumatic brain injury The University of Texas Health Science Center, Houston Completed No outcome recorded
Phase 1/2 NCT01028794 May 2008 → Jul 2013 intracranial embolism National Cerebral and Cardiovascular Center, Japan Completed No outcome recorded
Phase 29 trials
Phase 2 NCT03225651 Jul 2017 → Aug 2019 disease related to hematopoietic stem cell transplant Vinmec Research Institute of Stem Cell and Gene Technology Completed No outcome recorded
Phase 2 NCT02574923 Nov 2015 → Mar 2018 cerebral palsy Vinmec Healthcare System Completed No outcome recorded
Phase 2 NCT03123562 Apr 2014 → Sep 2016 cerebral palsy Vinmec Research Institute of Stem Cell and Gene Technology Completed No outcome recorded
Phase 2 NCT02627131 Apr 2014 → Dec 2015 autism Vinmec Healthcare System Completed No outcome recorded
Phase 2 NCT02569775 Apr 2014 → Aug 2015 cerebral palsy Vinmec Healthcare System Completed No outcome recorded
Phase 2 NCT01851083 Aug 2013 → Sep 2020 traumatic brain injury The University of Texas Health Science Center, Houston Completed No outcome recorded
Phase 2 NCT02009124 Aug 2012 → Jun 2018 spinal cord injury Neurogen Brain and Spine Institute Withdrawn No outcome recorded
Phase 2 NCT00979758 Jan 2009 → Jun 2015 myocardial infarction Chinese Academy of Medical Sciences, Fuwai Hospital Completed No outcome recorded
Phase 2 NCT01966042 Jul 2005 → Nov 2011 CellPraxis Bioengenharia Ltda. Completed No outcome recorded
Phase 31 trial
Phase 3 NCT02438306 Dec 2016 → Feb 2025 systolic heart failure BioCardia, Inc. Completed No outcome recorded

Evidence & citations 13 cited values

Every value below carries the sentence it was read from. 35 sources stand behind the page.

FieldValueCited text
Known as Autologous Bone Marrow Mononuclear Cells “OBJECTIVE: To test whether intensive atorvastatin (ATV) increases the efficacy of transplantation with autologous bone marrow mononuclear cells (MNCs) in patients suffering...” PMID 32393654 May 2020
22

“Direct injection of autologous bone marrow mononuclear cells into the myocardium may result in improved functional recovery, relieve symptoms, and improve other cardiovascular outcomes.” PMID 29803986 Apr 2018

“In this study, the effect of intrathecal administration of autologous bone marrow mononuclear cells (BMMNCs) is analyzed on the recovery process of patients with chronic stroke.” PMID 25126443 Jul 2014

“The intervention group underwent cellular transplantation consisting of intrathecal administration of autologous bone marrow mononuclear cells and standard neurorehabilitation.” PMID 29386049 Jan 2018

Autologous bone marrow mononuclear cells are administered intrathecally by a standard procedure followed by vigorous rehabilitation therapy.” NCT02009124

“The purpose of this study was to study the effect of autologous bone marrow mononuclear cells on common symptoms of cerebral palsy patients.” NCT02241395

Autologous bone marrow mononuclear cells are administered intrathecally by a standard procedure followed by standard rehabilitation therapy.” NCT02027246

“Transplantation of Autologous Bone Marrow Mononuclear cellsNCT05472428

“Transplantation of Autologous Bone Marrow Mononuclear CellsNCT03123562

“Transplantation of Autologous Bone Marrow Mononuclear cellsNCT03225651

“Transplantation of Autologous Bone Marrow Mononuclear CellsNCT04080921

NCT02574923

NCT01143168

NCT02569775

NCT01937416

NCT01575470

NCT00859014

NCT00832247

NCT01851083

NCT01028794

NCT01966042

NCT02627131

NCT02619734

Known as Autologous Bone Marrow derived Mono Nuclear Stem Cell “Intravenous transfer of Autologous Bone Marrow derived Mono Nuclear Stem Cell (BMMNCs)” NCT01876017
Known as autologous bone marrow-derived MNCs Autologous bone marrow-derived MNCs will be transplanted” NCT02323477
Known as autologous bone marrow-derived mononuclear cells autologous bone marrow-derived mononuclear cells (BMMC)” NCT00832247
Known as BM MNCs “Additionally, intrathecal infusion of autologous bone marrow mononuclear cells (BMMNCs) led to a slight decrease in TGF-β and GDF-15 levels in the CSF of ASD and CP patients,...” PMID 38114596 Dec 2023
10

“In this study, the effect of intrathecal administration of autologous bone marrow mononuclear cells (BMMNCs) is analyzed on the recovery process of patients with chronic stroke.” PMID 25126443 Jul 2014

“bone marrow derived mononuclear cells (BM-MNCs) transplantation” PMID 25678991 Oct 2014

“autologous bone marrow-derived mononuclear cells (BM-MNCs)” PMID 32840230 Nov 2020

“autologous bone marrow mononuclear cells (BM MNCs)” PMID 30107811 Aug 2018

“autologous bone marrow mononuclear cells (BMMNCs)” NCT01575470

NCT01958177

NCT04233892

NCT03880656

NCT01914913

NCT01876017

Known as BMMC “autologous bone marrow-derived mononuclear cells (BMMC)” NCT00832247
1

“autologous bone marrow mononuclear cell (BMMC)” PMID 31438885 Aug 2019

Known as Bone Marrow derived Mono Nuclear Stem Cell “Intravenous transfer of of Bone Marrow derived Mono Nuclear Stem Cell (BMMNCs)” NCT01958177
Known as bone marrow mononuclear cells “autologous bone marrow mononuclear cells (BM-MNCs)” NCT03880656
Known as bone marrow-derived mononuclear cells “autologous bone marrow-derived mononuclear cells (BM-MNCs)” PMID 32840230 Nov 2020
Known as CardiAMP cell therapy “treatment with the CardiAMP cell therapyNCT02438306
Known as MNCs “OBJECTIVE: To test whether intensive atorvastatin (ATV) increases the efficacy of transplantation with autologous bone marrow mononuclear cells (MNCs) in patients suffering...” PMID 32393654 May 2020
Modality Cell therapy “cellular therapy” NCT00832247
Route Intravenous “infused through a peripheral vein” NCT00832247