Drugs / ertumaxomab
last change Jul 2016 re-read 3 minutes ago

ertumaxomab

also known as ertu

Monoclonal antibody targets CD3E, ERBB2

Developed for
breast cancer
Investigated by
Neovii Biotech · Fresenius Biotech North America · Krankenhaus Nordwest

Trials 4

2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT01569412 Mar 2012 → May 2016 — Krankenhaus Nordwest Terminated No outcome recorded
Phase 23 trials
Phase 2 NCT00522457 Jan 2008 → Dec 2009 breast cancer Neovii Biotech Terminated No outcome recorded
Phase 2 NCT00452140 Mar 2007 → Feb 2009 breast cancer Neovii Biotech Terminated No outcome recorded
Phase 2 NCT00351858 Jul 2006 → Feb 2009 breast cancer Neovii Biotech Terminated No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Ertumaxomab ClinicalTrials.gov intervention name — accepted as the source's own label NCT01569412 ↗
3

NCT00452140 ↗

NCT00351858 ↗

NCT00522457 ↗

Known as ertu “BACKGROUND: Ertumaxomab (ertu) is a bispecific, trifunctional antibody targeting Her2/neu, CD3 and the Fcγ-receptors I, IIa, and III forming a tri-cell complex between tumor...” PMID 27387446 ↗ Jul 2016
Modality Monoclonal antibody “trifunctional anti-Her-2/neu x anti-CD3 antibody” NCT00351858 ↗
Route Intravenous “administered intravenously” NCT00351858 ↗
Target CD3E “T-cell surface glycoprotein CD3 epsilon chain cross-linking agent” CHEMBL2108029 ↗
Target ERBB2 “Receptor protein-tyrosine kinase erbB-2 cross-linking agent” CHEMBL2108029 ↗