Drugs / Estrone
Estrone
also known as
1,3,5-estratrien-3-ol-17-one · Estradiol metabolite e1 · Estrogenic substance · Estrona · Follicular hormone · Folliculin · Folliculinum · Ketohydroxyestrin · +6 more
Small molecule targets ESR1 via activation
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | THEELIN | — | 1941-06-12 | fda.gov ↗ |
Trials 1 · a red edge is where a trial was stopped
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2 | NCT00866437 | Apr 2009 → May 2010 | premenstrual tension | EVE Medical Systems Ltd. | Unknown | No outcome recorded |
Also used as a comparator or background therapy in 2 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT00873262 Comparator | Apr 2009 → May 2010 | premenstrual tension | EVE Medical Systems Ltd. | Unknown | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT02402049 Comparator | Mar 2015 → Mar 2016 | premenstrual tension | Shaare Zedek Medical Center | Unknown | No outcome recorded |
Evidence & citations 19 cited values
Every value below carries the sentence it was read from. 4 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Estrone | “Progesterone 1mmol/L; Estradiol 1mmol/L; Estrone 3mmol/L; Estriol 3mmol/L” NCT00873262 ↗1“3. Estrone 3 mmol/L” NCT00866437 ↗ |
| Known as | 1,3,5-estratrien-3-ol-17-one | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Known as | Estradiol metabolite e1 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Known as | Estrogenic substance | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Known as | Estrona | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Known as | Follicular hormone | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Known as | Folliculin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Known as | Folliculinum | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02402049 ↗ |
| Known as | Ketohydroxyestrin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Known as | Natural estrogenic substance-estrone | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Known as | NSC-9699 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Known as | Theelin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Known as | Thelykinin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Known as | Tokokin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Known as | WAY 164397 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1405 ↗ |
| Action | Activate | “Estrogen receptor alpha agonist” CHEMBL1405 ↗ |
| Modality | Small molecule | — CHEMBL1405 ↗ |
| Modality | Traditional medicine (herbal / TCM) | “receiving either Folliculinum that is given as general indication for PMS in homeopathy or placebo.” NCT02402049 ↗ |
| Target | ESR1 | “Estrogen receptor alpha agonist” CHEMBL1405 ↗ |