Drugs / BMS-986020
last change Mar 2022 re-read 2 minutes ago

BMS-986020

Small molecule targets LPAR1 via inhibition

Developed for
diffuse scleroderma · idiopathic pulmonary fibrosis
Investigated by
Bristol-Myers Squibb

Trials 6 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT02227173 Sep → Nov 2014 Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT02101125 Mar → May 2014 Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT02068053 Mar → Apr 2014 immunodeficiency disease Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT02017730 Jan 2014 → Jan 2015 Bristol-Myers Squibb Completed No outcome recorded
Phase 22 trials
Phase 2 NCT02588625 Feb 2016 → Oct 2019 diffuse scleroderma Bristol-Myers Squibb Withdrawn No outcome recorded
Phase 2 NCT01766817 Jan 2013 → Feb 2016 idiopathic pulmonary fibrosis Bristol-Myers Squibb Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as BMS-986020 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01766817
5

NCT02588625

NCT02227173

NCT02068053

NCT02017730

NCT02101125

Known as AP-3152 FREE ACID ChEMBL registry synonym — accepted as the source's own label CHEMBL4297270
Known as Bristol-Myers Squibb (BMS)-986020 Bristol-Myers Squibb (BMS)-986020 in healthy male subjects” NCT02068053
Action Inhibit “BMS-986020 potently inhibited LPA1-induced fibrogenesis.” PMID 35303880 Mar 2022
1

“Lysophosphatidic acid receptor Edg-2 antagonist” CHEMBL4297270

Modality Small molecule CHEMBL4297270
Route Oral “BMS-986020, 600 mg tablets, by mouth, once daily, 26 weeks” NCT01766817
Target LPAR1 “Lysophosphatidic acid receptor Edg-2 antagonist” CHEMBL4297270