Drugs / BMS-986020
last change Mar 2022 re-read 9 days ago

BMS-986020

Small molecule targets LPAR1 via inhibition

Developed for
diffuse scleroderma · idiopathic pulmonary fibrosis
Investigated by
Bristol-Myers Squibb

Trials 6

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT02227173 Sep → Nov 2014 — Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT02101125 Mar → May 2014 — Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT02068053 Mar → Apr 2014 immunodeficiency disease Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT02017730 Jan 2014 → Jan 2015 — Bristol-Myers Squibb Completed No outcome recorded
Phase 22 trials · 1 met primary
Phase 2 NCT02588625 Feb 2016 → Oct 2019 diffuse scleroderma Bristol-Myers Squibb Withdrawn No outcome recorded
Phase 2 NCT01766817 Jan 2013 → Feb 2016 idiopathic pulmonary fibrosis Bristol-Myers Squibb Completed Met primary

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as BMS-986020 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02588625 ↗
5

NCT02227173 ↗

NCT01766817 ↗

NCT02017730 ↗

NCT02101125 ↗

NCT02068053 ↗

Known as AP-3152 FREE ACID ChEMBL registry synonym — accepted as the source's own label CHEMBL4297270 ↗
Known as Bristol-Myers Squibb (BMS)-986020 “Bristol-Myers Squibb (BMS)-986020 in healthy male subjects” NCT02068053 ↗
Action Inhibit “BMS-986020 potently inhibited LPA1-induced fibrogenesis.” PMID 35303880 ↗ Mar 2022
1

“Lysophosphatidic acid receptor Edg-2 antagonist” CHEMBL4297270 ↗

Modality Small molecule — CHEMBL4297270 ↗
Route Oral “BMS-986020, 600 mg tablets, by mouth, once daily, 26 weeks” NCT01766817 ↗
Target LPAR1 “Lysophosphatidic acid receptor Edg-2 antagonist” CHEMBL4297270 ↗