Drugs / Azenosertib

Trials 17 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT05368506 Jul 2023 → Sep 2024 fallopian tube carcinoma, female breast carcinoma, ovarian carcinoma, primary peritoneal carcinoma +1 OHSU Knight Cancer Institute Withdrawn No outcome recorded
Phase 0 NCT04005690 Aug 2019 → Jun 2026 overdue pancreatic ductal adenocarcinoma OHSU Knight Cancer Institute Recruiting No outcome recorded
Phase 18 trials
Phase 1 NCT06364410 Feb 2025 → Jul 2027 expected gastric carcinoma, gastroesophageal junction adenocarcinoma, high grade malignant neoplasm, metastatic malignant neoplasm National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1 NCT06351332 May 2024 → Feb 2026 female breast carcinoma, triple-negative breast carcinoma Filipa Lynce, MD Terminated No outcome recorded
Phase 1 NCT05743036 Feb 2023 → Jul 2024 colorectal cancer K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc Terminated No outcome recorded
Phase 1 NCT05431582 Dec 2022 breast cancer, lung cancer, malignant pancreatic neoplasm, ovarian cancer M.D. Anderson Cancer Center Withdrawn No outcome recorded
Phase 1 NCT04833582 Aug 2021 → Aug 2023 osteosarcoma K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc Completed No outcome recorded
Phase 1 NCT04972422 Jul 2021 → Jun 2022 cancer Zentera Therapeutics HK Limited Unknown No outcome recorded
Phase 1 NCT04516447 Oct 2020 → Jun 2028 expected fallopian tube cancer, malignant epithelial tumor of ovary, peritoneum cancer K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc Recruiting No outcome recorded
Phase 1 NCT04158336 Nov 2019 → May 2025 cancer K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT05682170 Dec 2022 → Jul 2024 acute myeloid leukemia Zentalis Pharmaceuticals, Inc. Terminated No outcome recorded
Phase 1/2 NCT05198804 Jan 2022 → Oct 2025 fallopian tube cancer, ovarian cancer, primary peritoneal carcinoma K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc Completed No outcome recorded
Phase 24 trials
Phase 2 NCT06369155 Mar 2025 → Jan 2027 expected endometrial serous adenocarcinoma Joyce Liu, MD Recruiting No outcome recorded
Phase 2 NCT06015659 Nov 2023 → Aug 2025 overdue pancreatic ductal adenocarcinoma Brandon Huffman, MD Active not recruiting No outcome recorded
Phase 2 NCT05128825 Feb 2022 → Dec 2026 expected female reproductive organ cancer K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc Recruiting No outcome recorded
Phase 2 NCT04814108 Jul 2021 → Oct 2025 uterine cancer K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc Completed No outcome recorded
Phase 31 trial
Phase 3 NCT07546500 Apr 2026 → May 2028 expected ovarian cancer K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc Recruiting No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 18 sources stand behind the page.

FieldValueCited text
Known as Azenosertib ClinicalTrials.gov intervention name — accepted as the source's own label NCT06364410
10

NCT07546500

NCT04833582

NCT04814108

NCT04516447

NCT06351332

NCT05198804

NCT04158336

NCT04005690

NCT06369155

NCT05128825

Known as KP-2638 “This is a Phase 2 open-label, multicenter study to evaluate the clinical activity and safety of ZN-c3 (also known as azenosertib; KP-2638) in adult women with recurrent or...” NCT04814108
Known as ZN-c3 ZN-c3 (a small molecule inhibitor of the WEE1 tyrosine kinase)” NCT06015659
5

NCT05431582

NCT04972422

NCT05368506

NCT05743036

NCT05682170

Action Inhibit “Azenosertib is a selective and orally bioavailable inhibitor of WEE1.” NCT05128825
Modality Small molecule “a small molecule inhibitor of the WEE1 tyrosine kinase” NCT06015659
1

CHEMBL5095036

Route Oral “Azenosertib (ZN-c3) taken orally with food” NCT04814108
Target WEE1 “Azenosertib is a selective and orally bioavailable inhibitor of WEE1.” NCT05128825