Drugs / INS018_055
last change Aug 2026 re-read 3 minutes ago

INS018_055

also known as ISM001-055 · rentosertib

Small molecule targets TNIK via inhibition

Developed for
idiopathic pulmonary fibrosis
Investigated by
InSilico Medicine

Trials 3

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 22 trials
Phase 2 NCT05975983 Feb 2024 → Feb 2026 overdue idiopathic pulmonary fibrosis InSilico Medicine Recruiting No outcome recorded
Phase 2 NCT05938920 Jun 2023 → Aug 2024 idiopathic pulmonary fibrosis InSilico Medicine Completed No outcome recorded
Phase 31 trial
Phase 3 NCT07687459 Aug 2026 → Oct 2029 expected idiopathic pulmonary fibrosis InSilico Medicine Not yet recruiting No outcome recorded
Comparator or background therapy1 trial
Phase 1 NCT05154240 Comparator Feb → Dec 2022 idiopathic pulmonary fibrosis InSilico Medicine Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as INS018_055 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05975983 ↗
2

NCT07687459 ↗

NCT05154240 ↗

Known as ISM001-055 “Here we present the results of the first phase 2a multicenter, double-blind, randomized, placebo-controlled trial testing the safety and efficacy of rentosertib (formerly...” PMID 40461817 ↗ Jun 2025
Known as rentosertib “Here we present the results of the first phase 2a multicenter, double-blind, randomized, placebo-controlled trial testing the safety and efficacy of rentosertib (formerly...” PMID 40461817 ↗ Jun 2025
Action Inhibit “inhibitor of TNIK” PMID 40461817 ↗ Jun 2025
Modality Small molecule “a small molecule compound.” NCT05154240 ↗
Route Oral “administered as oral doses” NCT05154240 ↗
Target TNIK “inhibitor of TNIK” PMID 40461817 ↗ Jun 2025