Drugs / Foscarnet
Foscarnet
also known as
Foscarnet sodium · Foscavir · A-29622 · Dihydroxyphosphinecarboxylic acid oxide · EHB 776 · Foscarnet de sodio · Foscarnet sodique · Foscarnet sodium anhydrous · +6 more
Regulatory milestones approvals, filings & regulatory actions · 3 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansions (2) | US (FDA) | FOSCAVIR | — | 1995-06-16 – 1997-01-24 | fda.gov ↗ |
| Approved | US (FDA) | FOSCAVIR | — | 1991-09-27 | fda.gov ↗ |
Trials 22 · a red edge is where a trial was stopped
Also used as a comparator or background therapy in 8 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 23 trials | ||||||
| Phase 2 | NCT01220895 Background | Oct 2010 → Dec 2013 | cytomegalovirus infection | Cell Medica Ltd | Completed | No outcome recorded |
| Phase 2 | NCT00986557 Background | Sep 2009 → Aug 2013 | graft versus host disease | University Hospital Birmingham | Unknown | No outcome recorded |
| Phase 2 | NCT00001061 Background | ? → Mar 1998 | HIV infectious disease, cytomegalovirus retinitis | National Institute of Allergy and Infectious Diseases (NIAID) | Completed | No outcome recorded |
| Phase 33 trials | ||||||
| Phase 3 | NCT03073967 Comparator | May 2017 → Aug 2025 | herpes simplex infectious disease | AiCuris Anti-infective Cures AG | Completed | No outcome recorded |
| Phase 3 | NCT02931539 Comparator | Dec 2016 → Aug 2020 | cytomegalovirus infection | Shire | Completed | No outcome recorded |
| Phase 3 | NCT01077908 Background | Jul 2008 → Sep 2014 | cytomegalovirus infection | Cell Medica Ltd | Completed | No outcome recorded |
| Phase 42 trials | ||||||
| Phase 4 | NCT03004261 Background | Nov 2016 → Dec 2021 | cytomegalovirus infection, hematologic disorder | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | Completed | No outcome recorded |
| Phase 4 | NCT00002146 Background | — | HIV infectious disease, cytomegalovirus infection | Astra USA | Completed | No outcome recorded |
Evidence & citations 18 cited values
Every value below carries the sentence it was read from. 31 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Foscarnet | “Foscarnet intermittent infusions of 40 mg/kg every 8 hours or 60 mg/kg every 12 hours” NCT03073967 ↗26“Intravenous foscarnet 90 mg/kg twice daily” NCT01077908 ↗ “Intravenous foscarnet 90 mg/kg twice daily” NCT01220895 ↗ |
| Known as | A-29622 | ChEMBL registry synonym — accepted as the source's own label CHEMBL666 ↗ |
| Known as | Dihydroxyphosphinecarboxylic acid oxide | ChEMBL registry synonym — accepted as the source's own label CHEMBL666 ↗ |
| Known as | EHB 776 | ChEMBL registry synonym — accepted as the source's own label CHEMBL666 ↗ |
| Known as | Foscarnet de sodio | ChEMBL registry synonym — accepted as the source's own label CHEMBL666 ↗ |
| Known as | Foscarnet sodique | ChEMBL registry synonym — accepted as the source's own label CHEMBL666 ↗ |
| Known as | Foscarnet sodium | “Treated With Foscavir (Foscarnet Sodium)” NCT00002125 ↗ |
| Known as | Foscarnet sodium anhydrous | ChEMBL registry synonym — accepted as the source's own label CHEMBL666 ↗ |
| Known as | Foscarnet sodium hexahydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL666 ↗ |
| Known as | Foscarnet sodium hydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL666 ↗ |
| Known as | Foscarnet trisodium hexahydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL666 ↗ |
| Known as | Foscavir | “Phase III Multicenter, Open-Label, Randomized Trial of Induction Versus Induction Plus Maintenance Foscarnet ( Foscavir ) Therapy for Gastrointestinal CMV Disease” NCT00002145 ↗1“Treated With Foscavir (Foscarnet Sodium)” NCT00002125 ↗ |
| Known as | J05AD01 | ChEMBL registry synonym — accepted as the source's own label CHEMBL666 ↗ |
| Known as | NSC-313410 | ChEMBL registry synonym — accepted as the source's own label CHEMBL666 ↗ |
| Known as | NSC-758148 | ChEMBL registry synonym — accepted as the source's own label CHEMBL666 ↗ |
| Action | Inhibit | “by inhibiting the virus DNA polymerases” NCT00000726 ↗ |
| Modality | Small molecule | — CHEMBL666 ↗ |
| Route | Intravenous | “intravenous foscarnet induction at 90 mg/kg twice daily for 2 weeks, followed by maintenance therapy at 120 mg/kg/day” NCT00000134 ↗ |