Drugs / Plasmalyte
last change Jul 2026 re-read 2 minutes ago

Plasmalyte

Other / unclassified

Developed for
acute kidney injury · acute pancreatitis · cirrhosis of liver · disorder of acid-base balance · diabetic ketoacidosis · hypotensive disorder · infectious disease with sepsis
Investigated by
Assistance Publique - Hôpitaux de Paris · Baxter Healthcare Corporation · Alberta Children's Hospital · Ann & Robert H Lurie Children's Hospital of Chicago · Austin Health · Australian Government Department of Health and Ageing
+59 more · Australian and New Zealand Intensive Care Society Clinical Trials Group · Baylor College of Medicine · Boston Children's Hospital · British Columbia Children's Hospital · Centre Hospitalier Univeritaire Sainte Justine · Centre Hospitalier Universitaire de Quebec · Children's Healthcare of Atlanta · Children's Hospital Colorado · Children's Hospital Los Angeles · Children's Hospital Medical Center, Cincinnati · Children's Hospital and Health System Foundation, Wisconsin · Children's Hospital of Eastern Ontario · Children's Hospital of Philadelphia · Children's Medical Center Dallas · Children's National Research Institute · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Gold Coast Hospital and Health Service · Hasbro Children's Hospital · Health Research Council, New Zealand · Hospital do Coracao · Hospital nacional de niños Costa Rica · IWK Health Centre · Institute of Liver and Biliary Sciences, India · Jim Pattison Children's Hospital · Kidz First Hospital Middlemore · Kingston Health Sciences Centre · London Health Sciences Centre · McMaster Children's Hospital · Monash Children's Hospital · Morgan Stanley Children's Hospital · Nationwide Children's Hospital · Pennsylvania Department of Health · Perth Children's Hospital · Post Graduate Institute of Medical Education and Research, Chandigarh · Primary Children's Hospital · Queensland Children's Hospital · Royal Children's Hospital · Royal Darwin Hospital · Seattle Children's Hospital · Seoul St. Mary's Hospital · St. Louis Children's Hospital · Starship Children's Hospital · Stollery Children's Hospital · Sydney Children's Hospitals Network · The Children's Hospital of Winnipeg · The George Institute · The Hospital for Sick Children · The University of Queensland · Townsville University Hospital · University Hospital Olomouc · University Hospital Rijeka · University of California, Davis · University of California, San Francisco · University of Michigan · University of Pittsburgh · University of Rijeka · Virginia Commonwealth University · Westmead Children's Hospital · Women's and Children's Hospital, Australia

Trials 12 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 36 trials
Phase 3 NCT04102371 Aug 2020 → Dec 2025 Children's Hospital of Philadelphia Completed No outcome recorded
Phase 3 NCT03630224 Jun 2019 → Aug 2023 acute kidney injury Assistance Publique - Hôpitaux de Paris Terminated No outcome recorded
Phase 3 NCT03829488 Jan 2018 → Jul 2021 end stage renal failure The University of Queensland Completed No outcome recorded
Phase 3 NCT03118362 Aug 2017 → Sep 2018 Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 3 NCT02875873 May 2017 → Mar 2020 acute kidney injury Hospital do Coracao Completed No outcome recorded
Phase 3 NCT02691676 Jan → Dec 2014 disorder of acid-base balance University Hospital Olomouc Completed No outcome recorded
Phase 43 trials
Phase 4 NCT04688645 May 2020 → Dec 2022 acute pancreatitis University Hospital Rijeka Unknown No outcome recorded
Phase 4 NCT02721654 Sep 2017 → Mar 2021 The George Institute Completed No outcome recorded
Phase 4 NCT00885404 Feb → Aug 2009 Austin Health Unknown No outcome recorded
Phase not applicable3 trials
NCT06076330 Sep 2023 → Aug 2024 cirrhosis of liver Institute of Liver and Biliary Sciences, India Unknown No outcome recorded
NCT06097923 Nov 2021 → Dec 2022 Seoul St. Mary's Hospital Completed No outcome recorded
NCT02936167 Sep 2016 → Feb 2017 Post Graduate Institute of Medical Education and Research, Chandigarh Unknown No outcome recorded
Also used as a comparator or background therapy in 12 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT01087853 Comparator Mar 2010 → Mar 2011 disorder of acid-base balance, water intoxication University of Nottingham Completed No outcome recorded
Phase 21 trial
Phase 2 NCT03366220 Comparator Mar 2018 → Sep 2019 infectious disease with sepsis The University of Texas Health Science Center, Houston Terminated No outcome recorded
Phase 32 trials
Phase 3 NCT05752279 Comparator Mar 2024 → Jul 2026 overdue diabetic ketoacidosis The George Institute Recruiting No outcome recorded
Phase 3 NCT05355974 Background Aug 2022 → Jul 2024 hypotensive disorder, orthostatic hypotension 2, respiratory failure Wright State University Completed No outcome recorded
Phase 46 trials
Phase 4 NCT07189091 Comparator Oct 2025 → Apr 2028 expected University Hospital, Antwerp Recruiting No outcome recorded
Phase 4 NCT06080178 Comparator Nov 2023 → Oct 2026 expected Algemeen Ziekenhuis Maria Middelares Recruiting No outcome recorded
Phase 4 NCT03373318 Comparator Jan 2018 → Aug 2019 acute kidney injury Sant Pau Research Institute Unknown No outcome recorded
Phase 4 NCT02528448 Comparator Mar 2015 → Feb 2016 poisoning Regional Hospital Holstebro Unknown No outcome recorded
Phase 4 NCT02312999 Comparator Feb 2015 → Dec 2017 Brugmann University Hospital Completed No outcome recorded
Phase not applicable2 trials
NCT02726620 Background Jan → Dec 2017 hypotensive disorder Vanderbilt University Medical Center Completed No outcome recorded
NCT02463175 Background Jun 2015 → Jan 2016 acute kidney injury, scoliosis University of British Columbia Terminated No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 25 sources stand behind the page.

FieldValueCited text
Known as Plasmalyte “In Phase A, 12 subjects will receive 2 litres of 0.9% saline BP (Baxter Health Care, Thetford, UK) or Plasmalyte® (Baxter Health Care, Thetford, UK).” NCT01087853
19

“Balanced crystalloid solution (Plasmalyte) given as an initial bolus of 10 ml/kg body weight within the first 60 min after randomization” NCT04688645

“Usual care using balanced crystalloids (Iso-Lyte or Plasma-Lyte) only will follow Surviving Sepsis Campaign guidelines.” NCT03366220

“a bolus infusion was performed using 250ml of crystalloid fluid (PlasmaLyte).” NCT06097923

NCT03118362

NCT06080178

NCT02726620

NCT02875873

NCT02528448

NCT02936167

NCT02691676

NCT05355974

NCT02312999

NCT00885404

NCT03373318

NCT04102371

NCT07189091

NCT02135146

NCT06076330

NCT02463175

Known as Plasma-Lyte 148 “patients instead received a lactated solution (Hartmann solution), a balanced solution (Plasma-Lyte 148), and chloride-poor 20% albumin.” PMID 23073953 Oct 2012
3

NCT02721654

NCT05752279

NCT03829488

Known as Plasmalyte (Baxter Healthcare) Plasmalyte (Baxter Healthcare)NCT02691676
Known as Plasmalyte Viaflo ClinicalTrials.gov intervention name — accepted as the source's own label NCT03630224
Modality Other / unclassified “A baseline crystalloid infusion (plasmalyte®)” NCT02312999
Route Intravenous “This group will have intravenous plasmalyte fluid limited to a rate of 3 ml/kg/hr.” NCT02135146