Drugs / LINTUZUMAB ACTINIUM AC-225
LINTUZUMAB ACTINIUM AC-225
also known as
Lintuzumab AC 225 · 225 Ac-lintuzumab · 225 Actinium-lintuzumab · 225ac-hum195 · Actimab-a · Actinio (225ac) lintuzumab satetraxetan · Actinium (225ac) lintuzumab satetraxetan · Actinium ac 225 lintuzumab · +4 more
Other / unclassified targets CD33 via depletion
Trials 6 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 13 trials | ||||||
| Phase 1 | NCT06802523 | Apr 2026 → Dec 2028 | acute myeloid leukemia | National Cancer Institute (NCI) | Suspended | No outcome recorded |
| Phase 1 | NCT03441048 | May 2018 → May 2024 | acute myeloid leukemia | Medical College of Wisconsin | Completed | No outcome recorded |
| Phase 1 | NCT02998047 | Dec 2016 → May 2020 | plasma cell myeloma | Actinium Pharmaceuticals | Terminated | No outcome recorded |
| Phase 1/23 trials | ||||||
| Phase 1/2 | NCT03932318 | Mar → Dec 2023 | acute myeloid leukemia | Actinium Pharmaceuticals | Withdrawn | No outcome recorded |
| Phase 1/2 | NCT03867682 | Jan 2020 → Nov 2023 | acute myeloid leukemia | Actinium Pharmaceuticals | Unknown | No outcome recorded |
| Phase 1/2 | NCT02575963 | Oct 2012 → Nov 2018 | acute myeloid leukemia | Actinium Pharmaceuticals | Completed | No outcome recorded |
Evidence & citations 17 cited values
Every value below carries the sentence it was read from. 8 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | LINTUZUMAB ACTINIUM AC-225 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297554 ↗ |
| Known as | 225 Ac-lintuzumab | “225 Actinium-lintuzumab (225 Ac-lintuzumab) is a clinical stage radioimmunotherapy targeting CD33” PMID 33347715 ↗ Dec 2020 |
| Known as | 225 Actinium-lintuzumab | “225 Actinium-lintuzumab (225 Ac-lintuzumab) is a clinical stage radioimmunotherapy targeting CD33” PMID 33347715 ↗ Dec 2020 |
| Known as | 225ac-hum195 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297554 ↗ |
| Known as | Actimab-a | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297554 ↗ |
| Known as | Actinio (225ac) lintuzumab satetraxetan | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297554 ↗ |
| Known as | Actinium (225ac) lintuzumab satetraxetan | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297554 ↗ |
| Known as | Actinium ac 225 lintuzumab | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297554 ↗ |
| Known as | Actinium-225-labeled humanized anti-cd33 monoclonal antibody hum195 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297554 ↗ |
| Known as | Hum-195 ac-225 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297554 ↗ |
| Known as | Lintuzumab AC 225 | “This phase I trial tests the safety, side effects, and best dose of lintuzumab-Ac225 in combination with venetoclax and ASTX-727, and how well they work in treating patients...” NCT06802523 ↗6“Lintuzumab-Ac225 is an immunoconjugate \[antibody: anti-CD 33 antibody and radioactive isotope: Actinium (225Ac)\] for the treatment of multiple myeloma.” NCT02998047 ↗ “Drug: Lintuzumab AC 225” NCT02998047 ↗ |
| Known as | Lintuzumab satetraxetan ac-225 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297554 ↗ |
| Known as | SGN-33 AC-225 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297554 ↗ |
| Action | Deplete | “highly cytotoxic alpha radiation emitter that targets the cluster of differentiation 33 (CD33) cell surface antigen, which is expressed on leukemic cells” NCT03441048 ↗ |
| Modality | Other / unclassified | “Lintuzumab-Ac225 is an immunoconjugate \[antibody: anti-CD 33 antibody and radioactive isotope: Actinium (225Ac)\] for the treatment of multiple myeloma.” NCT02998047 ↗ |
| Route | Intravenous | “0.5 μCi/Kg IV infusion of Lintuzumab AC225 on Day 1 of each cycle” NCT02998047 ↗ |
| Target | CD33 | “Lintuzumab attaches to CD33 positive cancer cells” NCT06802523 ↗ |