Drugs / Remibrutinib

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) Rhapsido 2026-04-23 europa.eu
Approved US (FDA) RHAPSIDO 2025-09-30 fda.gov

Trials 32 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT07032272 Jul → Oct 2025 immune dysregulation, autoimmunity, and autoinflammation Novartis Pharmaceuticals Completed No outcome recorded
Phase 1 NCT05753592 Oct 2022 → Dec 2023 Novartis Pharmaceuticals Completed No outcome recorded
Phase 1 NCT03918980 Aug 2016 → Jan 2020 atopic eczema Novartis Pharmaceuticals Completed No outcome recorded
Phase 29 trials
Phase 2 NCT07681271 Jul 2026 → Dec 2027 expected rosacea Novartis Pharmaceuticals Recruiting No outcome recorded
Phase 2 NCT07222956 Jun 2026 → Oct 2030 expected primary progressive multiple sclerosis, relapsing-remitting multiple sclerosis, secondary progressive multiple sclerosis Moein Amin Not yet recruiting No outcome recorded
Phase 2 NCT06865651 May 2025 → Aug 2027 expected chronic urticaria Novartis Pharmaceuticals Recruiting No outcome recorded
Phase 2 NCT05432388 Oct 2022 → Mar 2025 food allergy Novartis Pharmaceuticals Completed No outcome recorded
Phase 2 NCT04109313 Oct 2019 → Sep 2022 chronic idiopathic urticaria Novartis Pharmaceuticals Completed No outcome recorded
Phase 2 NCT03944707 Jul 2019 → Apr 2020 asthma Novartis Pharmaceuticals Terminated No outcome recorded
Phase 2 NCT04035668 Jul 2019 → Nov 2021 Sjogren syndrome Novartis Pharmaceuticals Terminated No outcome recorded
Phase 2 NCT03926611 Jun 2019 → Jan 2021 chronic idiopathic urticaria Novartis Pharmaceuticals Completed No outcome recorded
Phase 2 NCT03827798 Feb 2019 → Dec 2024 overdue hidradenitis suppurativa Novartis Pharmaceuticals Active not recruiting No outcome recorded
Phase 319 trials
Phase 3 NCT07700056 Aug 2026 → Dec 2029 expected Novartis Pharmaceuticals Not yet recruiting No outcome recorded
Phase 3 NCT07665437 Jul 2026 → Oct 2031 expected hidradenitis suppurativa Novartis Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT07456891 Apr 2026 → Jan 2033 expected Novartis Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT07225504 Nov 2025 → Dec 2030 expected secondary progressive multiple sclerosis Novartis Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT06868212 Jul 2025 → Feb 2027 expected chronic idiopathic urticaria Novartis Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT06846281 Jun 2025 → Jul 2029 expected multiple sclerosis Novartis Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT06840392 Mar 2025 → Jun 2027 expected hidradenitis suppurativa Novartis Pharmaceuticals Active not recruiting No outcome recorded
Phase 3 NCT06744920 Feb 2025 → Feb 2028 expected generalized myasthenia gravis Novartis Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT06799000 Jan 2025 → May 2027 expected hidradenitis suppurativa Novartis Pharmaceuticals Active not recruiting No outcome recorded
Phase 3 NCT05976243 Dec 2023 → May 2026 overdue chronic inducible urticaria Novartis Pharmaceuticals Active not recruiting No outcome recorded
Phase not stated1 trial
NCT05170724 chronic urticaria Novartis Pharmaceuticals Available No outcome recorded

Press releases naming this drug 8 releases

DateIssuerRelease
2026-02-27 Novartis Pharmaceuticals Novartis receives positive CHMP opinion for remibrutinib in chronic spontaneous urticaria (CSU) novartis.com
2026-02-23 Novartis Pharmaceuticals Novartis presents Rhapsido® (remibrutinib) data at AAAAI, showing potential beyond chronic spontaneous urticaria (CSU) novartis.com
2026-02-18 Novartis Pharmaceuticals Novartis remibrutinib first therapy to achieve Phase III primary endpoint in chronic inducible urticaria (CIndU) novartis.com
2025-09-30 Novartis Pharmaceuticals Novartis receives FDA approval for Rhapsido® (remibrutinib), the only oral, targeted BTKi treatment for chronic spontaneous urticaria (CSU) novartis.com
2024-05-31 Novartis Pharmaceuticals Novartis Phase III data confirm sustained efficacy and long-term safety of oral remibrutinib in chronic spontaneous urticaria novartis.com
2023-11-09 Novartis Pharmaceuticals Novartis data show potential of remibrutinib as an oral treatment for chronic spontaneous urticaria providing significant symptom improvement as early as Week 2 novartis.com
2023-08-09 Novartis Pharmaceuticals Novartis remibrutinib Phase III trials met their primary endpoints and showed rapid symptom control in chronic spontaneous urticaria novartis.com
2021-09-30 Novartis Pharmaceuticals Novartis data show rapid and effective disease activity control with remibrutinib (LOU064) in patients with chronic spontaneous urticaria novartis.com

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 33 sources stand behind the page.

FieldValueCited text
Known as remibrutinib Remibrutinib (LOU064), an oral, highly selective Bruton tyrosine kinase inhibitor, offers fast disease control in patients with chronic spontaneous urticaria (CSU) who remain...” PMID 37866460 Oct 2023
20

“LOU064 (remibrutinib)” NCT05795153

NCT06840392

NCT04035668

NCT05976243

NCT07225504

NCT07456891

NCT05156281

NCT07700056

NCT06868212

NCT06846281

NCT05170724

NCT06042478

NCT07222956

NCT05753592

NCT06865651

NCT07665437

NCT06799000

NCT06744920

NCT07032272

NCT05147220

Known as LOU064 “A 52-week Multi-center, Randomized, Double-blind, Placebo Controlled, Basket Study With an Open-label Extension to Investigate the Efficacy, Safety, and Tolerability of...” NCT05976243
15

“Remibrutinib (LOU064), an oral, highly selective Bruton tyrosine kinase inhibitor, offers fast disease control in patients with chronic spontaneous urticaria (CSU) who remain...” PMID 37866460 Oct 2023

“The purpose of the core phase of the trial is to assess the efficacy, safety and tolerability of remibrutinib (LOU064) 25 milligrams (mg) twice a day (b.i.d.) over placebo for 24 weeks” NCT06042478

“Remibrutinib (LOU064) in Participants With Hepatic Impairment” NCT05753592

NCT05795153

NCT03827798

NCT05432388

NCT03918980

NCT03944707

NCT05677451

NCT05032157

NCT05048342

NCT05513001

NCT05030311

NCT03926611

NCT07681271

Known as LOU064-NXA ChEMBL registry synonym — accepted as the source's own label CHEMBL4483575
Known as NVP-LOU064-NXA ChEMBL registry synonym — accepted as the source's own label CHEMBL4483575
Action Inhibit “Remibrutinib (LOU064), an oral, highly selective Bruton tyrosine kinase inhibitor” PMID 37866460 Oct 2023
Modality Small molecule CHEMBL4483575
Route Oral “LOU064 25 mg administered orally” NCT03827798
Target BTK “Remibrutinib (LOU064), an oral, highly selective Bruton tyrosine kinase inhibitor” PMID 37866460 Oct 2023