Drugs / vonapanitase
vonapanitase
also known as
PRT-201 · Pancreatic elastase 1 · recombinant type I pancreatic elastase · Vonapanitasa
Protein / enzyme biologic targets ELN
Trials 3
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT01616290 | Oct 2012 → Jun 2014 | peripheral arterial disease | Proteon Therapeutics | Completed | No outcome recorded |
| Phase 1 | NCT02953496 | ? → Apr 2019 | peripheral arterial disease | Proteon Therapeutics | Withdrawn | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT01001351 | Sep 2009 → Nov 2012 | chronic kidney disease | Proteon Therapeutics | Completed | No outcome recorded |
| Comparator or background therapy5 trials | ||||||
| Phase 1 | NCT02956993 Comparator | Nov 2016 → Apr 2019 | peripheral arterial disease | Proteon Therapeutics | Completed | No outcome recorded |
| Phase 1/2 | NCT00679991 Comparator | Nov 2008 → Jul 2011 | chronic kidney disease | Proteon Therapeutics | Completed | No outcome recorded |
| Phase 2 | NCT01305824 Comparator | Mar 2011 → Nov 2012 | chronic kidney disease | Proteon Therapeutics | Completed | No outcome recorded |
| Phase 3 | NCT02414841 Comparator | Aug 2015 → Feb 2018 | chronic kidney disease | Proteon Therapeutics | Completed | No outcome recorded |
| Phase 3 | NCT02110901 Comparator | Jul 2014 → Dec 2016 | chronic kidney disease | Proteon Therapeutics | Completed | No outcome recorded |
Evidence & citations 8 cited values
Every value below carries the sentence it was read from. 10 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | vonapanitase | ClinicalTrials.gov intervention name — accepted as the source's own label NCT02953496 ↗ |
| Known as | Pancreatic elastase 1 | ChEMBL registry synonym — accepted as the source's own label CHEMBL3545070 ↗ |
| Known as | PRT-201 | “This research study is designed to assess the safety and effectiveness of an experimental drug called vonapanitase (PRT-201) in patients both receiving or expecting to receive...” NCT02414841 ↗ |
| Known as | recombinant type I pancreatic elastase | “OBJECTIVE: This study explored the safety and efficacy of recombinant type I pancreatic elastase (PRT-201) topically applied once to the external surface of an arteriovenous fistula.” PMID 24684771 ↗ Mar 2014 |
| Known as | Vonapanitasa | ChEMBL registry synonym — accepted as the source's own label CHEMBL3545070 ↗ |
| Modality | Protein / enzyme biologic | “recombinant human type-I pancreatic elastase” NCT01001351 ↗ |
| Route | Topical | “Applied topically to AVF during surgery” NCT00679991 ↗ |
| Target | ELN | “Elastin proteolytic enzyme” CHEMBL3545070 ↗ |