Drugs / Nerandomilast

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) Jascayd 2026-07-15 europa.eu
Approved US (FDA) JASCAYD 2025-10-07 fda.gov

Trials 35 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 123 trials
Phase 1 NCT07081932 Aug → Sep 2025 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT07100964 Aug → Sep 2025 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT06624072 Oct → Nov 2024 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT06408870 Jun → Aug 2024 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT06393127 Jun → Sep 2024 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT06415045 May → Jul 2024 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT06107036 Mar → Jul 2024 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT06139302 Dec 2023 → Feb 2024 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT06070610 Nov → Dec 2023 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT05707403 Feb → Mar 2023 Boehringer Ingelheim Completed No outcome recorded
Phase 23 trials
Phase 2 NCT06241560 Mar → Aug 2026 overdue idiopathic pulmonary fibrosis Boehringer Ingelheim Active not recruiting No outcome recorded
Phase 2 NCT06195072 Apr 2024 → Nov 2026 expected interstitial lung disease, scleroderma Scleroderma Research Foundation, Inc. Recruiting No outcome recorded
Phase 2 NCT04419506 Jul 2020 → Oct 2021 idiopathic pulmonary fibrosis Boehringer Ingelheim Completed No outcome recorded
Phase 38 trials
Phase 3 NCT07540988 Aug 2026 → Dec 2028 expected interstitial lung disease Boehringer Ingelheim Not yet recruiting No outcome recorded
Phase 3 NCT07366034 Jul 2026 → Apr 2029 expected pulmonary fibrosis Boehringer Ingelheim Not yet recruiting No outcome recorded
Phase 3 NCT07497087 Jul 2026 → Feb 2030 expected systemic sclerosis Boehringer Ingelheim Not yet recruiting No outcome recorded
Phase 3 NCT07201922 Feb 2026 → May 2029 expected pulmonary fibrosis Boehringer Ingelheim Recruiting No outcome recorded
Phase 3 NCT06806592 Sep 2025 → Jul 2027 expected autoimmune interstitial lung disease-arthritis syndrome, interstitial lung disease Boehringer Ingelheim Recruiting No outcome recorded
Phase 3 NCT06238622 May 2024 → Apr 2027 expected idiopathic pulmonary fibrosis, pulmonary fibrosis Boehringer Ingelheim Recruiting No outcome recorded
Phase 3 NCT05321082 Nov 2022 → Dec 2024 interstitial lung disease Boehringer Ingelheim Completed No outcome recorded
Phase 3 NCT05321069 Oct 2022 → Aug 2024 idiopathic pulmonary fibrosis Boehringer Ingelheim Completed No outcome recorded
Phase 41 trial
Phase 4 NCT07570888 Jun 2026 → Jun 2027 expected pulmonary fibrosis University of British Columbia Not yet recruiting No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2/31 trial
Phase 2/3 NCT07321860 Comparator Jun 2026 → Jun 2027 expected amyotrophic lateral sclerosis Gipfel Life Sciences GmbH Not yet recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT07299695 Comparator Jan 2026 → Jun 2028 expected idiopathic pulmonary fibrosis Argyrios Tzouvelekis Recruiting No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 39 sources stand behind the page.

FieldValueCited text
Known as Nerandomilast “Study participants will take the active investigational product BI 1015550 (Nerandomilast) or matching placebo provided as film-coated tablets, administered orally BID.” NCT06195072
15

“Antifibrotics (nintedanib, pirfenidone, or nerandomilast) will be continued during hospitalization if already prescribed and not contraindicated.” NCT07299695

Nerandomilast (BI 1015550), an oral preferential inhibitor of phosphodiesterase 4B, is being evaluated in two randomized Phase III trials” PMID 41345848 Dec 2025

NCT06806592

NCT07321860

NCT07201922

NCT06238622

NCT06624072

NCT07540988

NCT07100964

NCT07497087

NCT07570888

NCT06139302

NCT06393127

NCT07366034

NCT07081932

Known as BI 1015550 “Nerandomilast (BI 1015550), an oral preferential inhibitor of phosphodiesterase 4B, is being evaluated in two randomized Phase III trials” PMID 41345848 Dec 2025
23

“three 6 milligram BI 1015550 film-coated tablets of Trial Formulation 2 (TF2) taken orally” NCT05428436

“Drug: BI1015550” NCT01835899

NCT03422068

NCT04771286

NCT01835899

NCT06107036

NCT03230487

NCT05707403

NCT05661344

NCT04419506

NCT05718648

NCT06241560

NCT06070610

NCT03403439

NCT05550636

NCT05633862

NCT03302078

NCT01594515

NCT03542344

NCT06415045

NCT05321069

NCT06408870

NCT06195072

Action Inhibit inhibitor of the PDE4B subtype” PMID 35569036 May 2022
Modality Small molecule CHEMBL5314532
Route Oral “Single Rising Oral Doses” NCT01594515
Target PDE4B “inhibitor of the PDE4B subtype” PMID 35569036 May 2022