Drugs / SX-682
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SX-682

Small molecule targets CXCR1, CXCR2 via inhibition

Developed for
non-small cell lung carcinoma · prostate carcinoma · adenoid cystic carcinoma · castration-resistant prostate carcinoma · colon adenocarcinoma · colorectal cancer · hypopharyngeal carcinoma · laryngeal carcinoma
+12 more · metastatic malignant neoplasm · metastatic melanoma · myelodysplastic syndrome · nasopharyngeal carcinoma · oral cavity squamous cell carcinoma · oropharynx squamous cell carcinoma · pancreatic adenocarcinoma · pancreatic ductal adenocarcinoma · paranasal sinus neoplasm · plasma cell myeloma · rectum adenocarcinoma · salivary gland cancer
Investigated by
Syntrix Biosystems, Inc. · National Cancer Institute (NCI) · Bristol-Myers Squibb · M.D. Anderson Cancer Center · Mayo Clinic · University of Miami
+22 more · University of Rochester · University of Washington · AdventHealth · BeiGene · Belfast Health and Social Care Trust · Cambridge University Hospitals NHS Foundation Trust · Dana-Farber Cancer Institute · Emory University · Genentech, Inc. · H. Lee Moffitt Cancer Center and Research Institute · Institute of Cancer Research, United Kingdom · Institute of Oncology Research (IOR) · Janssen Pharmaceutica N.V., Belgium · Lei Zheng · Massachusetts General Hospital · Montefiore Medical Center · National Heart, Lung, and Blood Institute (NHLBI) · Oncology Institute of Southern Switzerland · Prostate Cancer UK · Roswell Park Cancer Institute · Royal Marsden NHS Foundation Trust · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Trials 13 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT06622005 Apr 2025 → Apr 2027 expected plasma cell myeloma Roswell Park Cancer Institute Recruiting No outcome recorded
Phase 1 NCT04477343 Nov 2020 → May 2026 overdue pancreatic ductal adenocarcinoma University of Rochester Active not recruiting No outcome recorded
Phase 1 NCT04245397 Jun 2020 → Mar 2028 expected myelodysplastic syndrome Syntrix Biosystems, Inc. Recruiting No outcome recorded
Phase 1 NCT03161431 Jun 2019 → Aug 2026 overdue metastatic melanoma Syntrix Biosystems, Inc. Active not recruiting No outcome recorded
Phase 1/25 trials
Phase 1/2 NCT07667400 Jul 2026 → Oct 2036 expected adenoid cystic carcinoma, castration-resistant prostate carcinoma, hypopharyngeal carcinoma, laryngeal carcinoma +5 National Cancer Institute (NCI) Not yet recruiting No outcome recorded
Phase 1/2 NCT07002320 Apr 2025 → Oct 2029 expected prostate carcinoma Institute of Cancer Research, United Kingdom Recruiting No outcome recorded
Phase 1/2 NCT06149481 Mar 2024 → Oct 2027 expected colorectal cancer National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1/2 NCT04574583 Nov 2020 → Feb 2023 metastatic malignant neoplasm National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT04599140 Oct 2020 → Jul 2026 overdue colon adenocarcinoma, rectum adenocarcinoma M.D. Anderson Cancer Center Active not recruiting No outcome recorded
Phase 24 trials
Phase 2 NCT07322341 Sep 2026 → Nov 2030 expected non-small cell lung carcinoma University of Washington Not yet recruiting No outcome recorded
Phase 2 NCT06228053 Nov 2024 → Jun 2027 expected prostate carcinoma Syntrix Biosystems, Inc. Recruiting No outcome recorded
Phase 2 NCT05604560 Nov 2023 → Sep 2026 expected pancreatic adenocarcinoma Lei Zheng Active not recruiting No outcome recorded
Phase 2 NCT05570825 Apr 2023 → Jul 2027 expected non-small cell lung carcinoma University of Washington Recruiting No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 13 sources stand behind the page.

FieldValueCited text
Known as SX-682 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05604560
12

NCT04599140

NCT04574583

NCT03161431

NCT07667400

NCT06149481

NCT07322341

NCT07002320

NCT05570825

NCT04477343

NCT06228053

NCT04245397

NCT06622005

Action Inhibit “SX-682 is an oral small molecule selective inhibitor of C-X-C Motif Chemokine Receptor 1 (CXCR1) and C-X-C Motif Chemokine Receptor 2 (CXCR2)” NCT03161431
Modality Small molecule “SX-682 is an oral small molecule selective inhibitor” NCT03161431
Route Oral “SX-682 is an oral small molecule” NCT03161431
Target CXCR1 “selective inhibitor of C-X-C Motif Chemokine Receptor 1 (CXCR1)” NCT03161431