drugset
Drugs / Depelestat
last change Sep 2007 re-read 3 minutes ago

Depelestat

also known as DX-890 · EPI-hNE4

targets ELANE via inhibition

Developed for
adult acute respiratory distress syndrome · pulmonary fibrosis

Trials 0

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Comparator or background therapy1 trial
Phase 2 NCT00455767 Comparator Jul 2006 → Sep 2007 adult acute respiratory distress syndrome, pulmonary fibrosis Debiopharm International SA Completed No outcome recorded

Press releases naming this drug 6 releases

DateIssuerRelease
2005-12-20 Debiopharm International SA Debiopharm and Dyax Corp. restructure development agreement for Depelestat (EPI-hNE4 or DX-890) in pulmonary disorders debiopharm.com ↗
2004-02-24 Debiopharm International SA Dyax Corp. and Debiopharm S.A. report positive Results from Phase IIa Clinical Trial with DX-890 (EPI-hNE4) in Children with Cystic Fibrosis debiopharm.com ↗
2003-12-15 Debiopharm International SA Debiopharm S.A. and Dyax Corp. granted orphan drug designation for DX-890 (EPI-HNE4) by U.S. FDA – Cystic Fibrosis designation debiopharm.com ↗
2003-07-29 Debiopharm International SA Debiopharm S.A. and Dyax Corp. granted European Orphan Drug Status for EPI-hNE4 (DX-890) for Cystic Fibrosis Indication debiopharm.com ↗
2002-07-15 Debiopharm International SA Dyax Corp. and Debiopharm S.A. report successful results of phase IIA clinical trial with DX-890 for cystic fibrosis debiopharm.com ↗
2002-05-14 Debiopharm International SA Debiopharm S.A. reports study revealing that EPI-HNE4 offers protection against acute lung injury debiopharm.com ↗

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as Depelestat “I.V. injection of 1mg/kg Depelestat (EPI-hNE4) 3 times daily for 7 days” NCT00455767 ↗
Known as DX-890 ChEMBL registry synonym — accepted as the source's own label CHEMBL2108025 ↗
Known as EPI-hNE4 “I.V. injection of 1mg/kg Depelestat (EPI-hNE4) 3 times daily for 7 days” NCT00455767 ↗
Action Inhibit “Leukocyte elastase inhibitor” CHEMBL2108025 ↗
Route Intravenous “I.V. injection” NCT00455767 ↗
Target ELANE “Leukocyte elastase inhibitor” CHEMBL2108025 ↗