Drugs / Fluorouracil (5-FU)
last change Jul 2026 re-read 3 minutes ago

Fluorouracil (5-FU)

also known as 5-fluorouracil
Developed for
reactive cutaneous fibrous lesion
Investigated by
University of California, Davis

Trials 1

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase not applicable1 trial
— NCT07660120 Jul 2026 → Jul 2027 expected reactive cutaneous fibrous lesion University of California, Davis Not yet recruiting No outcome recorded
Comparator or background therapy1 trial
Phase 1 NCT01274624 Background Dec 2010 → Feb 2018 colorectal cancer Oncolytics Biotech Completed Met primary

Press releases naming this drug 7 releases

DateIssuerRelease
2016-10-18 Takeda Shire Granted EU Marketing Authorization of ONIVYDE®, In Combination With 5-Fluorouracil (5-FU) And Leucovorin (LV), For The Treatment of Metastatic Adenocarcinoma Of The Pancreas in Adult Patients Who Have Progressed Following Gemcitabine-Based Therapy takeda.com ↗
2015-12-11 Orphan Australia BTG Announces FDA Approval of VISTOGARD® (Uridine Triacetate) as Antidote to Overdose and Early Onset, Severe, or Life-Threatening Toxicities from Chemotherapy Drugs 5-Fluorouracil (5-FU) serb.com ↗
2015-09-10 Orphan Australia BTG Announces FDA Acceptance of Wellstat Therapeutics’ New Drug Application for Uridine Triacetate as Antidote to Overexposure to Chemotherapy Drug 5-Fluorouracil (5-FU) serb.com ↗
2014-01-18 Nektar Therapeutics Nektar Presents Positive Clinical Data from a Phase 1 Study of Etirinotecan Pegol (NKTR-102) in Combination with 5-Fluorouracil/Leucovorin at the 2014 Gastrointestinal Cancers Symposium nektar.com ↗
2011-11-08 Bristol-Myers Squibb FDA Approves ERBITUX® (cetuximab) for First-Line Recurrent Locoregional or Metastatic Head and Neck Cancer in Combination with Platinum-based Chemotherapy with 5-Fluorouracil bms.com ↗
2011-11-07 Eli Lilly and Company FDA Approves ERBITUX® (cetuximab) for First-Line Recurrent Locoregional or Metastatic Head and Neck Cancer in Combination with Platinum-based Chemotherapy with 5-Fluorouracil lilly.com ↗
2010-06-24 Nektar Therapeutics Nektar Announces Dosing of First Patients in Phase 1 Clinical Study of NKTR-102 in Combination With 5-Fluorouracil/Leucovorin nektar.com ↗

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as Fluorouracil (5-FU) ClinicalTrials.gov intervention name — accepted as the source's own label NCT07660120 ↗
1

NCT01274624 ↗

Known as 5-fluorouracil “Another medication, called 5-fluorouracil (5-FU), has been shown in prior studies to work well when combined with steroids, but it is usually given by injection, which can be...” NCT07660120 ↗
Route Intravenous “400 mg/m2 intravenous bolus followed by 2400 mg/m2 as a continuous intravenous infusion over 46 hours administered on Day 1 every 2 weeks.” NCT01274624 ↗