Drugs / AK117

Trials 19 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT04728334 Mar 2021 → Jan 2022 cancer Akeso Completed No outcome recorded
Phase 1 NCT04349969 Apr 2020 → Nov 2022 cancer Akeso Biopharma, Inc. Completed No outcome recorded
Phase 1/27 trials
Phase 1/2 NCT06642792 Jan 2025 → Nov 2027 expected classic Hodgkin lymphoma Akeso Recruiting No outcome recorded
Phase 1/2 NCT06387420 Apr 2024 → Apr 2026 overdue acute myeloid leukemia Akeso Not yet recruiting No outcome recorded
Phase 1/2 NCT05229497 May 2022 → Dec 2026 expected cancer Akeso Active not recruiting No outcome recorded
Phase 1/2 NCT05235542 Mar 2022 → May 2026 cancer Akeso Completed No outcome recorded
Phase 1/2 NCT05214482 Jan 2022 → Nov 2025 cancer Akeso Completed No outcome recorded
Phase 1/2 NCT04980885 Aug 2021 → Sep 2025 overdue acute myeloid leukemia Akeso Active not recruiting No outcome recorded
Phase 1/2 NCT04900350 Jun 2021 → Sep 2025 overdue myelodysplastic syndrome Akeso Active not recruiting No outcome recorded
Phase 27 trials
Phase 2 NCT07245446 Oct 2025 → Dec 2027 expected small cell lung carcinoma Akeso Recruiting No outcome recorded
Phase 2 NCT06789848 Feb 2025 → May 2029 expected biliary tract cancer, hepatocellular carcinoma University of Texas Southwestern Medical Center Recruiting No outcome recorded
Phase 2 NCT06508606 Aug 2024 → Aug 2026 overdue head and neck squamous cell carcinoma West China Hospital Not yet recruiting No outcome recorded
Phase 2 NCT06196203 Feb 2024 → Jan 2026 overdue myelodysplastic syndrome Akeso Recruiting No outcome recorded
Phase 2 NCT05960955 Nov 2023 → Nov 2024 overdue gastroesophageal adenocarcinoma Akeso Recruiting No outcome recorded
Phase 2 NCT05382442 Jun 2022 → May 2026 overdue colorectal cancer Akeso Active not recruiting No outcome recorded
Phase 2 NCT05227664 Mar 2022 → Dec 2026 expected triple-negative breast carcinoma Akeso Active not recruiting No outcome recorded
Phase 33 trials
Phase 3 NCT07264075 May 2026 → May 2030 expected head and neck squamous cell carcinoma Groupe Oncologie Radiotherapie Tete et Cou Recruiting No outcome recorded
Phase 3 NCT06953999 Jun 2025 → May 2027 expected malignant pancreatic neoplasm Akeso Recruiting No outcome recorded
Phase 3 NCT06601335 Oct 2024 → Jan 2027 expected head and neck squamous cell carcinoma Akeso Recruiting No outcome recorded

Press releases naming this drug 2 releases

DateIssuerRelease
2022-01-10 Akeso CD47单抗(AK117)联合PD-1/VEGF双抗(AK112)联合或不联合化疗治疗恶性肿瘤的Ib/II临床研究获批开展 akesobio.com
2021-12-24 Akeso 康方生物发布CD47单抗(AK117)药物机制研究成果 akesobio.com

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 19 sources stand behind the page.

FieldValueCited text
Known as AK117 “Ligufalimab (AK117) 45 mg/kg IV over 120 minutes on Day 1 every 3 weeks” NCT06789848
17

NCT06508606

NCT04349969

NCT06642792

NCT07245446

NCT04980885

NCT06387420

NCT05229497

NCT06953999

NCT04900350

NCT06601335

NCT04728334

NCT06196203

NCT05214482

NCT05960955

NCT05382442

NCT05235542

NCT05227664

Known as Ligufalimab ClinicalTrials.gov intervention name — accepted as the source's own label NCT06789848
1

NCT07264075

Action Inhibit “AK117#Anti-CD47 Antibody#” NCT05229497
Modality Monoclonal antibody “AK117 (Anti-CD47 Monoclonal Antibody)” NCT06642792
Route Intravenous “AK117 monotherapy intravenous (IV) infusion- weekly doses in a 28-day cycle.” NCT04349969
Target CD47 “AK117 (Anti-CD47)” NCT04900350