Drugs / BI 1701963
last change Aug 2026 re-read 2 minutes ago

BI 1701963

Small molecule targets KRAS, SOS1 via inhibition

Developed for
cancer · cancer of unknown primary site · colorectal cancer · lung cancer · malignant colon neoplasm · metastatic malignant neoplasm
Investigated by
Boehringer Ingelheim · Amgen · Mirati Therapeutics Inc.

Trials 6 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT04973163 Sep 2021 → Nov 2026 expected Boehringer Ingelheim Active not recruiting No outcome recorded
Phase 1 NCT04975256 Jul 2021 → Nov 2022 cancer of unknown primary site, lung cancer, malignant colon neoplasm, metastatic malignant neoplasm Mirati Therapeutics Inc. Terminated No outcome recorded
Phase 1 NCT04835714 Apr 2021 → Jan 2022 Boehringer Ingelheim Terminated No outcome recorded
Phase 1 NCT04627142 Nov 2020 → Jan 2022 colorectal cancer Boehringer Ingelheim Terminated No outcome recorded
Phase 1 NCT04185883 Dec 2019 → Dec 2026 expected cancer Amgen Active not recruiting No outcome recorded
Phase 1 NCT04111458 Nov 2019 → Dec 2027 expected Boehringer Ingelheim Active not recruiting No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as BI 1701963 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04627142
5

NCT04975256

NCT04111458

NCT04835714

NCT04973163

NCT04185883

Action Inhibit “BI 1701963 is a small-molecule son of sevenless 1 (SOS1) inhibitor” PMID 42048384 Aug 2026
Modality Small molecule “BI 1701963 is a small-molecule” PMID 42048384 Aug 2026
Route Oral “During this time, they get tablets of BI 1701963 and trametinib once daily.” NCT04111458
Target SOS1 “selectively binds to SOS1PMID 42048384 Aug 2026