Drugs / Panax notoginseng saponins
Panax notoginseng saponins
also known as
PNS · TSPN · Xuesaitong soft capsule · Xueshuantong Injection · Xueshuantong injections
Trials 6
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT06618495 | Dec 2024 → Nov 2025 | acute coronary syndrome | Xiyuan Hospital of China Academy of Chinese Medical Sciences | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT03083119 | Mar → Apr 2017 | intermediate coronary syndrome | Jie Wang | Unknown | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT06845254 | Mar → Oct 2025 overdue | acute coronary syndrome | Xiyuan Hospital of China Academy of Chinese Medical Sciences | Not yet recruiting | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT02999048 | May 2014 → May 2016 | — | The First People's Hospital of Jingzhou | Completed | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT02544087 | Apr 2015 → Apr 2018 | ischemic stroke | Yunling Zhang | Unknown | No outcome recorded |
| — | NCT01636154 | Jan 2012 → Mar 2016 | ischemic stroke | Yunling Zhang | Completed | No outcome recorded |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 9 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Panax Notoginseng Saponins | “Panax Notoginseng Saponins, Specification:0.33 per bag, once take two pills and twice a day during a month.” NCT03083119 ↗ |
| Known as | PNS | “Panax notoginseng Saponins (PNS) may have an inhibitory effect against coronary artery disease (CAD); however, the mechanism is unclear.” PMID 35784716 ↗ Jun 2022 |
| Known as | TSPN | “Total saponins of Panax notoginseng (TSPN), main constituents extracted from Panax Notoginseng, a highly valued traditional Chinese medicine, have been shown to be an effective...” PMID 19059471 ↗ Nov 2008 |
| Known as | Xuesaitong soft capsule | “Xuesaitong soft capsule (main ingredient is Panax notoginseng saponins)” NCT06845254 ↗ |
| Known as | Xueshuantong Injection | “heat-clearing Ixeris of sonchifolia Hance(Kudiezi Injection) and blood-activating Panax notoginseng saponins(Xueshuantong Injection)as the therapeutic interventions” NCT02544087 ↗ |
| Known as | Xueshuantong injections | “Xueshuantong injections” NCT02544087 ↗ |
| Action | Inhibit | “It was suggested that PNS could reduce leukocyte adhesion in venules under the inhibitory effect on the expression of adhesion molecules (CD11b and CD18) on neutrophils.” PMID 16543624 ↗ 2006 |
| Modality | Traditional medicine (herbal / TCM) | “heat-clearing and blood-activating Chinese medicinal components” NCT02544087 ↗ |
| Route | Intravenous | “Xueshuantong450mg+0.9%N.S.250ml,ivdrip,qd” NCT02544087 ↗ |
| Target | MAPK1 | “Six genes, including MAPK1, RAS, and FASL, were common targets of PNS in CAD sequencing.” PMID 35784716 ↗ Jun 2022 |