Drugs / 15.GPC3-CAR T cells
last change Oct 2025 re-read 3 minutes ago

15.GPC3-CAR T cells

also known as GO-CART T cells

Cell therapy targets GPC3 via depletion

Developed for
brain glioblastoma
Investigated by
Baylor College of Medicine · Baylor St. Luke's Medical Center · Center for Cell and Gene Therapy, Baylor College of Medicine

Trials 1

20262027202820292030
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT06815432 Oct 2025 → Dec 2029 expected brain glioblastoma Baylor College of Medicine Recruiting No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 1 source stands behind the page.

FieldValueCited text
Known as 15.GPC3-CAR T cells ClinicalTrials.gov intervention name — accepted as the source's own label NCT06815432 ↗
Known as GO-CART T cells “This study will test T cells with the IL15 GPC3-CAR (GO-CART T cells) in participants with GPC3-positive brain tumors.” NCT06815432 ↗
Action Deplete “we can put a new gene (a tiny part of what makes-up DNA and carries the participants traits) into T cells that will make them recognize cancer cells and kill them.” NCT06815432 ↗
Modality Cell therapy “This study will test T cells genetically engineered with a GPC3-CAR and IL15 (GO-CART T cells) in participants with GPC3-positive brain tumors.” NCT06815432 ↗
Route Other “the cells will then be thawed and administered in the participants tumor area, called an intracavitary administration” NCT06815432 ↗
Target GPC3 “This study will test T cells genetically engineered with a GPC3-CAR and IL15 (GO-CART T cells) in participants with GPC3-positive brain tumors.” NCT06815432 ↗