Drugs / DYN101
last change Nov 2025 re-read 3 minutes ago

DYN101

Antisense oligonucleotide targets DNM2

Developed for
centronuclear myopathy
Investigated by
Dynacure

Trials 2

2020202120222023202420252026
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/2 NCT04743557 Jan 2024 → Sep 2025 centronuclear myopathy Dynacure Withdrawn No outcome recorded
Phase 1/2 NCT04033159 Jan 2020 → Jun 2022 centronuclear myopathy Dynacure Terminated No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as DYN101 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04033159 ↗
1

NCT04743557 ↗

Modality Antisense oligonucleotide “DYN101 is a synthetically manufactured constrained ethyl gapmer antisense oligonucleotide (ASO)” NCT04033159 ↗
Route Intravenous “for intravenous (IV) administration” NCT04033159 ↗
Target DNM2 “DYN101, is a constrained ethyl gapmer ASO directed against human DNM2 RNA” NCT04033159 ↗