Drugs / Cemsidomide
last change 11 days ago re-read 9 days ago

Cemsidomide

also known as Cemsidomida · CFT7455

Small molecule targets IKZF1

Developed for
plasma cell myeloma · non-Hodgkin lymphoma
Investigated by
C4 Therapeutics, Inc.

Trials 3

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT07280013 Feb 2026 → Dec 2028 expected plasma cell myeloma C4 Therapeutics, Inc. Recruiting No outcome recorded
Phase 1 NCT04756726 Apr 2021 → Sep 2026 overdue non-Hodgkin lymphoma, plasma cell myeloma C4 Therapeutics, Inc. Active not recruiting No outcome recorded
Phase 21 trial
Phase 2 NCT07284758 Feb 2026 → Mar 2030 expected plasma cell myeloma C4 Therapeutics, Inc. Recruiting No outcome recorded

News releases announcing trial results or a regulatory action · 2

DateIssuerRelease
2026-09-25 C4 Therapeutics, Inc. Results C4 Therapeutics Presents New Biomarker Data from the Cemsidomide Phase 1 Trial with Dexamethasone and Phase 1b Trial with Elranatamab (ELREXFIO®) in Relapsed/Refractory Multiple Myeloma at the 23rd International Myeloma Society (IMS) Annual Meeting c4therapeutics.com ↗
In 62 heavily pre-treated RRMM patients across the once-daily (QD) dose levels, cemsidomide demonstrated coordinated activation of T cells, including CD8+ T cells, and functional reprogramming of natural killer (NK) cells.
2026-06-11 C4 Therapeutics, Inc. Results C4 Therapeutics Presents Phase 1 Data at European Hematology Association (EHA) 2026 Congress Highlighting Cemsidomide as a Potential Best-in-Class IKZF1/3 Degrader for Multiple Myeloma in Heavily Pretreated Relapsed/Refractory Population c4therapeutics.com ↗
At the 100 µg Recommended Phase 2 Dose (RP2D), Cemsidomide Demonstrated a 53% Overall Response Rate, Including Complete Responses and Minimal Residual Disease (MRD) Negative Status

All press releases naming this drug 6 releases

DateIssuerRelease

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as cemsidomide ClinicalTrials.gov intervention name — accepted as the source's own label NCT04756726 ↗
2

NCT07284758 ↗

NCT07280013 ↗

Known as Cemsidomida ChEMBL registry synonym — accepted as the source's own label CHEMBL5095227 ↗
Known as CFT7455 ChEMBL registry synonym — accepted as the source's own label CHEMBL5095227 ↗
Modality Small molecule — CHEMBL5095227 ↗
Route Oral “oral cemsidomide” NCT04756726 ↗
Target IKZF1 “IKZF1/3 degrader” NCT07280013 ↗