Drugs / Linperlisib
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Linperlisib

also known as YY 20394 · PI3K.DELTA.-IN-2

Small molecule

Developed for
peripheral T-cell lymphoma, not otherwise specified · follicular lymphoma · T-cell large granular lymphocyte leukemia · diffuse large B-cell lymphoma · extranodal nasal NK/T cell lymphoma · lymphoma · mantle cell lymphoma · neoplasm
+15 more · non-Hodgkin lymphoma · aggressive B-cell non-Hodgkin lymphoma · autoimmune hemolytic anemia · B-cell chronic lymphocytic leukemia · B-cell non-Hodgkin lymphoma · chronic lymphocytic leukemia/small lymphocytic lymphoma · chronic lymphoproliferative disorder of NK-cells · indolent B-cell non-Hodgkin lymphoma · lymphoplasmacytic lymphoma · marginal zone lymphoma · mature T-cell and NK-cell non-Hodgkin lymphoma · Nodal T-follicular helper cell lymphoma, follicular type · plasma cell myeloma · primary acquired red cell aplasia · T-lymphoblastic lymphoma
Investigated by
Shanghai YingLi Pharmaceutical Co. Ltd. · Institute of Hematology & Blood Diseases Hospital, China · Sun Yat-sen University · Peking Union Medical College Hospital · YL-Pharma · Jiangsu HengRui Medicine Co., Ltd.
+16 more · Ruijin Hospital · The First Affiliated Hospital with Nanjing Medical University · Beijing Tongren Hospital · Dalian Medical University · Dongguan People's Hospital · Fujian Cancer Hospital · Fujian Provincial Hospital · Fuling Zhou · Huizhou Municipal Central Hospital · Jieyang People's Hospital · Peking University · Shanxi Province Cancer Hospital · The First Affiliated Hospital of Xiamen University · The First Hospital of Jilin University · Yanyan Liu · Zhangzhou Affiliated Hospital of Fujian Medical University

Trials 36 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT06793956 Feb 2025 → Jan 2026 overdue extranodal nasal NK/T cell lymphoma Sun Yat-sen University Recruiting No outcome recorded
Phase 1 NCT06712173 Dec 2024 → Sep 2025 overdue peripheral T-cell lymphoma, not otherwise specified Institute of Hematology & Blood Diseases Hospital, China Not yet recruiting No outcome recorded
Phase 1 NCT05676710 Feb 2023 → Jan 2024 T-cell large granular lymphocyte leukemia Institute of Hematology & Blood Diseases Hospital, China Completed No outcome recorded
Phase 1 NCT05676697 Jan 2023 → Jan 2024 autoimmune hemolytic anemia Institute of Hematology & Blood Diseases Hospital, China Terminated No outcome recorded
Phase 1 NCT05429398 Jun 2022 → Aug 2023 neoplasm Shanghai YingLi Pharmaceutical Co. Ltd. Unknown No outcome recorded
Phase 1 NCT04279405 Jun 2020 → Sep 2021 chronic lymphocytic leukemia/small lymphocytic lymphoma, diffuse large B-cell lymphoma, lymphoplasmacytic lymphoma, mantle cell lymphoma +1 Shanghai YingLi Pharmaceutical Co. Ltd. Completed No outcome recorded
Phase 1 NCT04108325 Mar 2020 → Jun 2021 peripheral T-cell lymphoma, not otherwise specified Shanghai YingLi Pharmaceutical Co. Ltd. Unknown No outcome recorded
Phase 1 NCT04049929 Aug 2019 → Oct 2020 neoplasm Shanghai YingLi Pharmaceutical Co. Ltd. Unknown No outcome recorded
Phase 1 NCT03757000 Dec 2017 → Mar 2019 B-cell chronic lymphocytic leukemia Shanghai YingLi Pharmaceutical Co. Ltd. Unknown No outcome recorded
Phase 1/212 trials
Phase 1/2 NCT07209163 Oct 2025 → Mar 2026 overdue peripheral T-cell lymphoma, not otherwise specified Ruijin Hospital Not yet recruiting No outcome recorded
Phase 1/2 NCT07139353 Sep 2025 → Sep 2027 expected peripheral T-cell lymphoma, not otherwise specified Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 1/2 NCT06981988 Jun → Aug 2025 overdue non-Hodgkin lymphoma Jiangsu HengRui Medicine Co., Ltd. Not yet recruiting No outcome recorded
Phase 1/2 NCT06799676 Feb 2025 → Aug 2027 expected plasma cell myeloma Fuling Zhou Not yet recruiting No outcome recorded
Phase 1/2 NCT06592170 Aug 2024 → Aug 2025 overdue lymphoma The First Hospital of Jilin University Recruiting No outcome recorded
Phase 1/2 NCT06421948 May 2024 → May 2027 expected peripheral T-cell lymphoma, not otherwise specified Yanyan Liu Recruiting No outcome recorded
Phase 1/2 NCT06376721 Apr 2024 → Oct 2026 expected T-lymphoblastic lymphoma, extranodal nasal NK/T cell lymphoma Beijing Tongren Hospital Recruiting No outcome recorded
Phase 1/2 NCT06083701 Sep 2023 → Sep 2024 peripheral T-cell lymphoma, not otherwise specified Peking Union Medical College Hospital Unknown No outcome recorded
Phase 1/2 NCT05949944 Aug 2023 → Aug 2026 overdue peripheral T-cell lymphoma, not otherwise specified Sun Yat-sen University Recruiting No outcome recorded
Phase 1/2 NCT06037239 Jul 2023 → Jul 2024 lymphoma Peking Union Medical College Hospital Unknown No outcome recorded
Phase 213 trials
Phase 2 NCT07031115 Sep → Dec 2025 overdue primary acquired red cell aplasia Peking Union Medical College Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07195799 Dec 2024 → Dec 2027 expected non-Hodgkin lymphoma The First Affiliated Hospital with Nanjing Medical University Recruiting No outcome recorded
Phase 2 NCT06530550 Aug 2024 → Aug 2026 overdue T-cell large granular lymphocyte leukemia, chronic lymphoproliferative disorder of NK-cells Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded
Phase 2 NCT06489808 May 2024 → Dec 2026 expected aggressive B-cell non-Hodgkin lymphoma Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded
Phase 2 NCT06324994 May 2024 → May 2025 overdue mantle cell lymphoma Dalian Medical University Not yet recruiting No outcome recorded
Phase 2 NCT06224257 Dec 2023 → Oct 2025 overdue T-cell large granular lymphocyte leukemia Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded
Phase 2 NCT06347653 Nov 2023 → Jan 2027 expected Nodal T-follicular helper cell lymphoma, follicular type Peking University Recruiting No outcome recorded
Phase 2 NCT06158386 Nov 2023 → Dec 2027 expected follicular lymphoma The First Affiliated Hospital of Xiamen University Recruiting No outcome recorded
Phase 2 NCT05274997 May 2022 → Jan 2023 mature T-cell and NK-cell non-Hodgkin lymphoma Shanghai YingLi Pharmaceutical Co. Ltd. Unknown No outcome recorded
Phase 2 NCT04948788 Oct 2021 → Apr 2023 B-cell non-Hodgkin lymphoma Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT06548347 Sep → Dec 2024 overdue peripheral T-cell lymphoma, not otherwise specified Shanghai YingLi Pharmaceutical Co. Ltd. Not yet recruiting No outcome recorded
Phase 41 trial
Phase 4 NCT06343935 Apr 2024 indolent B-cell non-Hodgkin lymphoma Shanghai YingLi Pharmaceutical Co. Ltd. Unknown No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 37 sources stand behind the page.

FieldValueCited text
Known as Linperlisib Linperlisib 80mg QD orally, or Duvelisib 25mg BID orally” NCT06530550
25

NCT06037239

NCT05949944

NCT07139353

NCT06592170

NCT06981988

NCT06793956

NCT05559008

NCT06083701

NCT06347653

NCT06548347

NCT06799676

NCT07031115

NCT06489808

NCT06421948

NCT07195799

NCT06376721

NCT06712173

NCT06224257

NCT06324994

NCT05676697

NCT06343935

NCT07209163

NCT06158386

NCT05676710

NCT05429398

Known as PI3K.DELTA.-IN-2 ChEMBL registry synonym — accepted as the source's own label CHEMBL4574601
Known as YY 20394 YY 20394 has high potency against PI3K-δ, but with markedly improved selectivity in in vitro assays compared to idelalisib.” NCT04379167
10

NCT04108325

NCT05274997

NCT04279405

NCT03757000

NCT04379167

NCT04948788

NCT04370405

NCT04049929

NCT04500561

NCT04705090

Action Inhibit “YY-20394 is a selective inhibitor of the delta isoform of phosphatidylinositol 3- kinase (PI3Kδ).” NCT03757000
Modality Small molecule “oral small molecular inhibitor” NCT04108325
Route Oral “YY-20394 is given orally once daily.” NCT03757000