Drugs / Olaptesed pegol
last change Jan 2026 re-read 3 minutes ago

Olaptesed pegol

also known as NOX-A12 FREE ACID

targets CXCL12 via inhibition

Developed for
malignant pancreatic neoplasm · colorectal cancer · glioblastoma
Investigated by
TME Pharma AG · Merck Sharp & Dohme LLC

Trials 3

2017201820192020202120222023202420252026202720282029
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/22 trials
Phase 1/2 NCT04121455 Sep 2019 → Dec 2028 expected glioblastoma TME Pharma AG Active not recruiting No outcome recorded
Phase 1/2 NCT03168139 Apr 2017 → Mar 2020 colorectal cancer, malignant pancreatic neoplasm TME Pharma AG Completed No outcome recorded
Phase 21 trial
Phase 2 NCT04901741 Jan 2026 → Mar 2028 expected malignant pancreatic neoplasm TME Pharma AG Not yet recruiting No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as Olaptesed pegol ClinicalTrials.gov intervention name — accepted as the source's own label NCT04901741 ↗
2

NCT04121455 ↗

NCT03168139 ↗

Known as NOX-A12 FREE ACID ChEMBL registry synonym — accepted as the source's own label CHEMBL4594485 ↗
Action Inhibit “inactivation of CXCL12 by olaptesed pegol” NCT03168139 ↗
Route Intravenous “Olaptesed pegol continuous i.v. administration” NCT04121455 ↗
Target CXCL12 “Olaptesed pegol (NOX-A12) targets a key chemokine in the tumor microenvironment, CXCL12” NCT03168139 ↗