Drugs / Resatorvid
last change Feb 2026 re-read 2 minutes ago

Resatorvid

also known as TAK-242 · Cli-095

Small molecule targets TLR4 via inhibition

Developed for
infectious disease with sepsis · liver disorder · alcoholic hepatitis · alcoholic liver cirrhosis
Investigated by
Takeda · Akaza Bioscience Ltd · IQVIA Pty Ltd · Stefan Heber

Trials 4 · a red edge is where a trial was stopped

2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT07092215 Jun → Jul 2025 Stefan Heber Completed No outcome recorded
Phase 21 trial
Phase 2 NCT04620148 Dec 2021 → Dec 2022 liver disorder Akaza Bioscience Ltd Unknown No outcome recorded
Phase 32 trials
Phase 3 NCT00633477 Feb 2008 → Feb 2009 infectious disease with sepsis Takeda Terminated No outcome recorded
Phase 3 NCT00143611 Sep 2005 → Feb 2007 infectious disease with sepsis Takeda Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT06890039 Comparator Sep 2025 → Feb 2026 overdue alcoholic hepatitis, alcoholic liver cirrhosis Yaqrit Ltd Not yet recruiting No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Resatorvid ClinicalTrials.gov intervention name — accepted as the source's own label NCT00633477
2

NCT07092215

NCT00143611

Known as Cli-095 ChEMBL registry synonym — accepted as the source's own label CHEMBL225157
Known as TAK-242 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04620148
1

NCT06890039

Action Inhibit “acts by inhibiting TLR-4 mediated signaling” NCT00143611
Modality Small molecule “TAK-242 (resatorvid) is a small molecule suppressor of pathogen-induced release of inflammatory cytokines” NCT00143611
Route Subcutaneous “injection, subcutaneously for thirty minutes” NCT00143611
Target TLR4 “Resatorvid This TLR4 antagonist” NCT07092215