donor lymphocytes

Developed for: myelodysplastic syndrome · acute myeloid leukemia · acute erythroid leukemia · acute lymphoblastic leukemia · acute megakaryoblastic leukemia in adult · acute myeloblastic leukemia with maturation · acute myeloblastic leukemia without maturation · acute myeloid leukemia with 11q23 abnormalities
+13 more
· acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) · acute myeloid leukemia with minimal differentiation · acute myeloid leukemia with t(8;21)(q22;q22) translocation · acute myeloid leukemia, del(5q31-q32) · acute myeloid leukemia, t(16;16)(p13.1;q22) · acute myelomonocytic leukemia M4 · adult acute lymphoblastic leukemia · adult acute monocytic leukemia · childhood acute lymphoblastic leukemia · chronic myeloid leukemia · hematopoietic and lymphoid cell neoplasm · leukemia · plasma cell neoplasm
Investigated by: National Cancer Institute (NCI) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium · M.D. Anderson Cancer Center · Roswell Park Cancer Institute · Rutgers Cancer Institute of New Jersey · Rutgers, The State University of New Jersey
+1 more
· St. Petersburg State Pavlov Medical University

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Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 1/22 trials
Phase 1/2	NCT05009719	Apr 2021 → Apr 2023	hematopoietic and lymphoid cell neoplasm	St. Petersburg State Pavlov Medical University	Completed	No outcome recorded
Phase 1/2	NCT00923910	Feb 2008 → Oct 2013	acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia, myelodysplastic syndrome	National Cancer Institute (NCI)	Completed	No outcome recorded
Phase 22 trials
Phase 2	NCT02684162	Jun 2016 → Oct 2024	acute myeloid leukemia, chronic myelomonocytic leukemia, myelodysplastic syndrome	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 2	NCT00031655	Sep 2001 → Aug 2006	adult acute lymphoblastic leukemia, childhood acute lymphoblastic leukemia	Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium	Completed	No outcome recorded
Phase not applicable2 trials
—	NCT02105116	Feb 2014 → Dec 2015	acute erythroid leukemia, acute megakaryoblastic leukemia in adult, acute myeloblastic leukemia with maturation, acute myeloblastic leukemia without maturation +8	Rutgers, The State University of New Jersey	Terminated	No outcome recorded
—	NCT00534118	Oct 2003 → Jul 2018	leukemia, myelodysplastic syndrome, plasma cell neoplasm	Roswell Park Cancer Institute	Completed	No outcome recorded

Also used as a comparator or background therapy in 2 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 11 trial
Phase 1	NCT00476177 Background	Jul 2003 → Aug 2007	hematopoietic and lymphoid system neoplasm	Dana-Farber Cancer Institute	Completed	No outcome recorded
Phase 21 trial
Phase 2	NCT00006252 Background	Feb 2001 → Jan 2007	leukemia, lymphoma	Cancer and Leukemia Group B	Completed	No outcome recorded

Every value below carries the sentence it was read from. 8 sources stand behind the page.

Field	Value	Cited text
Known as	Donor lymphocytes	ClinicalTrials.gov intervention name — accepted as the source's own label NCT05009719 ↗ 7 NCT00006252 ↗ NCT02684162 ↗ NCT00031655 ↗ NCT00923910 ↗ NCT00476177 ↗ NCT00534118 ↗ NCT02105116 ↗
Modality	Cell therapy	“minimal ablation and cellular immune therapy with allogeneic donor stem cell therapy” NCT00006252 ↗
Route	Intravenous	“donor lymphocytes IV over 2 hours” NCT00006252 ↗