Drugs / UV-4
last change Aug 2022 re-read 3 minutes ago

UV-4

Small molecule

Investigated by
Emergent BioSolutions · Quintiles, Inc. · Unither Virology

Trials 1

2015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT02061358 Jul 2014 → Jul 2015 viral infectious disease Emergent BioSolutions Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as UV-4 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02061358 ↗
Known as MON-DNJ “BACKGROUND: UV-4 (N-(9'-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate” PMID 35939501 ↗ Aug 2022
Known as N-(9'-methoxynonyl)-1-deoxynojirimycin “BACKGROUND: UV-4 (N-(9'-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate” PMID 35939501 ↗ Aug 2022
Known as UV-4 hydrochloride “Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects.” PMID 35939501 ↗ Aug 2022
Known as UV-4B “Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects.” PMID 35939501 ↗ Aug 2022
Action Inhibit “The antiviral mechanism of action of UV-4 is through inhibition of the host endoplasmic reticulum-resident α-glucosidase 1 and α-glucosidase 2 enzymes.” PMID 35939501 ↗ Aug 2022
Modality Small molecule “is an iminosugar small-molecule oral drug candidate” PMID 35939501 ↗ Aug 2022