Drugs / JNJ-26483327
JNJ-26483327
Small molecule targets EGFR, ERBB2, ERBB4, FLT4, FYN, LCK, LYN, SRC, YES1 via inhibition
Trials 1
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1 | NCT00676299 | Aug 2006 → Jul 2008 | cancer | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Completed | No outcome recorded |
Evidence & citations 13 cited values
Every value below carries the sentence it was read from. 2 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | JNJ-26483327 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00676299 ↗ |
| Action | Inhibit | “JNJ-26483327, a multi-targeted reversible kinase inhibitor, is a new drug in development for treatment of cancer.” NCT00676299 ↗9“Vascular endothelial growth factor receptor 3 inhibitor” CHEMBL3109738 ↗ “Receptor protein-tyrosine kinase erbB-4 inhibitor” CHEMBL3109738 ↗ “Receptor protein-tyrosine kinase erbB-2 inhibitor” CHEMBL3109738 ↗ “Epidermal growth factor receptor erbB1 inhibitor” CHEMBL3109738 ↗ “Tyrosine-protein kinase FYN inhibitor” CHEMBL3109738 ↗ “Tyrosine-protein kinase Lyn inhibitor” CHEMBL3109738 ↗ “Tyrosine-protein kinase SRC inhibitor” CHEMBL3109738 ↗ “Tyrosine-protein kinase YES inhibitor” CHEMBL3109738 ↗ “Tyrosine-protein kinase LCK inhibitor” CHEMBL3109738 ↗ |
| Modality | Small molecule | — CHEMBL3109738 ↗ |
| Route | Oral | “Patients will take JNJ-26483327 capsules by mouth twice a day throughout treatment.” NCT00676299 ↗ |
| Target | EGFR | “Epidermal growth factor receptor erbB1 inhibitor” CHEMBL3109738 ↗ |
| Target | ERBB2 | “Receptor protein-tyrosine kinase erbB-2 inhibitor” CHEMBL3109738 ↗ |
| Target | ERBB4 | “Receptor protein-tyrosine kinase erbB-4 inhibitor” CHEMBL3109738 ↗ |
| Target | FLT4 | “Vascular endothelial growth factor receptor 3 inhibitor” CHEMBL3109738 ↗ |
| Target | FYN | “Tyrosine-protein kinase FYN inhibitor” CHEMBL3109738 ↗ |
| Target | LCK | “Tyrosine-protein kinase LCK inhibitor” CHEMBL3109738 ↗ |
| Target | LYN | “Tyrosine-protein kinase Lyn inhibitor” CHEMBL3109738 ↗ |
| Target | SRC | “Tyrosine-protein kinase SRC inhibitor” CHEMBL3109738 ↗ |
| Target | YES1 | “Tyrosine-protein kinase YES inhibitor” CHEMBL3109738 ↗ |