Drugs / Omigapil
Omigapil
Trials 5
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial · 1 met primary | ||||||
| Phase 1 | NCT01805024 | Dec 2014 → Dec 2017 | congenital muscular dystrophy | Santhera Pharmaceuticals | Completed | Met primary |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT00407212 | Jan 2002 → Nov 2003 | Parkinson disease | Novartis | Completed | No outcome recorded |
| Phase 23 trials | ||||||
| Phase 2 | NCT00230074 | Nov 2004 → Feb 2005 | amyotrophic lateral sclerosis | Novartis | Completed | No outcome recorded |
| Phase 2 | NCT00072709 | Sep 2003 → Dec 2004 | amyotrophic lateral sclerosis | Novartis Pharmaceuticals | Completed | No outcome recorded |
| Phase 2 | NCT00036413 | Jan → Oct 2002 | amyotrophic lateral sclerosis | Novartis Pharmaceuticals | Completed | No outcome recorded |
Evidence & citations 8 cited values
Every value below carries the sentence it was read from. 7 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Omigapil | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01805024 ↗ |
| Known as | Cgp-3466 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1232111 ↗ |
| Known as | dibenz[b,f]oxepin-10-ylmethyl-prop-2-ynyl-amine, hydrogen maleate salt | “TCH346 (dibenz[b,f]oxepin-10-ylmethyl-prop-2-ynyl-amine, hydrogen maleate salt)” NCT00407212 ↗ |
| Known as | Omigapilo | ChEMBL registry synonym — accepted as the source's own label CHEMBL1232111 ↗ |
| Known as | TCH346 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00230074 ↗ |
| Action | Inhibit | “Omigapil is a small molecule which inhibits the GAPDH-Siah1-mediated apoptosis pathway.” PMID 38915423 ↗ May 2024 |
| Modality | Small molecule | “Omigapil is a small molecule which inhibits the GAPDH-Siah1-mediated apoptosis pathway.” PMID 38915423 ↗ May 2024 |
| Route | Oral | “Three Oral Doses (0.5 mg, 2.5 mg and 10 mg Once Daily) of TCH346” NCT00036413 ↗ |